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Jim,
Since
you asked for comments and Philippe was kind enough to supple a copy of the
abstract, I will take up your request.
Forgive me for having a skeptical eye, but
the possible effect would be a response of the immune system to cell damage
for the 0.5 Gy (50 rad) exposure. Again, whether this is a good or bad
response is going to be based on several factors and what is the eventual
outcome is to the animal. Did the mice live longer? Did they develop
any malignancies? I would be interested to see a fractionation of the dose
over different intervals to see how the levels of glutathione changed.
I really know little of
the functioning of glutathione in normal and diseases animals. Obviously it is exists at some normal level in
the body. What function dose is normally play? Does it destroy
damaged cells in the body, or only foreign pathogens? What is the
mechanism that causes levels to change?
As always, a interesting
abstract.
Have a good weekend.
-- John
John Jacobus, MS
Certified Health Physicist
3050 Traymore
Lane
Bowie, MD 20715-2024
E-mail: jenday1@email.msn.com
(H)
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Here is the Medline abstract:
1: Radiat Res 2002 Mar;157(3):275-280 |
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Elevation of Glutathione Induced by
Low-Dose Gamma Rays and its Involvement in Increased Natural Killer
Activity.
Kojima S, Ishida H, Takahashi M, Yamaoka
K.
Faculty of Pharmaceutical Sciences, Tokyo University of Science,
Noda-shi, Chiba 278-0022, Japan;; Author to whom correspondence should be
addressed at Faculty of Pharmaceutical Sciences, Tokyo University of Science,
Noda-shi, Chiba 278-0022, Japan; kjma@rs.noda.sut.ac.jp
Kojima, S.,
Ishida, H., Takahashi, M. and Yamaoka, K. Elevation of Glutathione Induced by
Low-Dose Gamma Rays and its Involvement in Increased Natural Killer Activity.
Radiat. Res. 157, 275[?]--[?]280 (2002).We examined the relationship between
the induction of an increase in the level of glutathione and the elevation of
natural killer (NK) activity in mouse splenocytes by a low dose of [gamma]
rays. The glutathione levels in mouse splenocytes increased significantly
between 2 h and 6 h after whole-body [gamma] irradiation at 0.5 Gy, peaked at
4 h, and then decreased almost to the level before irradiation by 12 h
postirradiation. A significant enhancement of NK activity was found in the
splenocytes obtained from whole-body-irradiated mice between 4 and 6 h
postirradiation. Reduced glutathione (GSH) added exogenously to splenocytes
obtained from normal mice enhanced both the total cellular glutathione content
and the NK activity in a dose-dependent manner. Other precursors of de novo
GSH synthesis, such as cysteine, N-acetylcysteine and oxidized glutathione,
also increased the activity. These enhancements were completely blocked by
buthionine sulfoximine, an inhibitor of de novo GSH synthesis. We conclude
that the induction of endogenous glutathione in living cells immediately after
low-dose [gamma] irradiation is at least partially responsible for the
appearance of enhanced NK activity.
PMID: 11839089 [PubMed - as
supplied by publisher]
. . .
Your comments are most
welcome.
Regards, Jim
Muckerheide
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