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Re: dose limits for public & ODL
Howard,
Sorry, but I made a typo in my earlier message. It should have read that
the optimal dose level (ODL) for most persons would lie somewhere between
1.0 and 100 rem/a (0.01-1.0 Sv/a), with
10 rem/a being the log-mean of that rather broad range. Of course, for
individuals, the ODL would likely be dependent on dose rate and many other
factors. In any case, I believe that future radiation protection programs
will focus on achieving ODL rather than setting dose limits. Unfortunately,
I doubt that most of us will live to see that happen. Jerry
----- Original Message -----
From: <hflong@postoffice.pacbell.net>
To: <Jack_Earley@RL.GOV>
Cc: <jjcohen@PRODIGY.NET>; <sandyfl@EARTHLINK.NET>;
<radsafe@list.vanderbilt.edu>
Sent: Friday, February 15, 2002 10:30 PM
Subject: Re: dose limits for members of the public
> Optimal Dose Level (ODL) -acute- was, indeed, 1-9 rads where 34 instead of
expected 42.3 breast cancers were found in bomb survivors, for example.
>
> Low dose rate ODL, however, might be many times that.
> Taiwan apartments gave up to 600 rem, if I recall Luan correctly.
> My patients having radiation oncology get about 10 x the acutely fatal
dose, but spread over a couple of dozen daily treatments. If one were to
> extrapolate linearly (smile!) -.
>
> If db placebo studies confirm benefit I expect, 10 rem
> radiohormesis therapy will have a very comfortable 10 x safety margin.
Compare that with niacin or statin (to reduce cholesterol), where just 2x
the
> effective dose for one person may make another nauseous (even the same
individual at different times, as with flu).
>
> So, I would favor radiation supplement up to 10 rem/year -
> 1/10 of the symptom producing acute dose.
>
> Howard Long
>
> Jack_Earley@RL.GOV wrote:
>
> > I wouldn't expect it to be much different from similar "optimum" levels
in
> > supplements, FDA guidelines, or medication label instructions.
Especially
> > since those levels change as we gain more information. I think we'd see
> > standard applications of supplementary radiation, w/ the boilerplate
"check
> > w/ your doctor," etc. Or by prescription only unless it became as
> > commonplace as tanning booths.
> >
> > Jack Earley
> > Radiological Engineer
> >
> > -----Original Message-----
> > From: Jerry Cohen [mailto:jjcohen@PRODIGY.NET]
> > Sent: Tuesday, February 12, 2002 5:22 PM
> > To: Sandy Perle; radsafe@list.vanderbilt.edu
> > Subject: Re: dose limits for members of the public
> >
> > Sandy,
> > You seem surprised that anyone might view 1.0 rem/a as an
appropriate
> > dose limit for general population. Those of us who believe in hormesis
(a
> > small but steadfast minority) hold that there is likely to be an optimal
> > dose level at which people will derive the maximum benefit ( and least
> > detriment) from radiation exposure.
> > Perhaps you may recall some previous discussions on radsafe
regarding
> > possible methods of supplying supplementary radiation to those living in
> > radiation deficient areas. I suppose it seemed like a joke to many but
I,
> > for one, seriously think that at some future time, the hormesis concept
will
> > become generally accepted and we will be thinking in terms of optimal
dose
> > levels. Unfortunately, that time will not arrive until LNT, ALARA, etc
> > becomes unprofitable for its proponents, and that will likely be a long
> > time from now.
> > However, when that time comes, the idea of dose limits will become
> > outmoded and research will be directed toward determination of what
> > constitutes optimal dose level (ODL). Some thoughts (conjectures) on the
> > subject: [1] ODL will likely vary between individuals and/or population
> > groups,[2] it will be recognized that DNA aberration is not the only
> > biological effect of radiation and that there are a multiplicity of
effects
> > to various organs and tissues; some beneficial, some detrimental in
nature,
> > [3] the net effect (i.e. sum of all effects) will be dependent upon dose
> > level, age, and the state of the recipient's health, [4] I believe that
for
> > most persons the ODL would be somewhere greater than 1.0 rem/a and less
than
> > 10.0 rem/a (well above current background levels).
> > Anyone else have any thoughts on the ODL concept, pro or con?
> >
> > ----- Original Message -----
> > From: Sandy Perle <sandyfl@EARTHLINK.NET>
> > To: <radsafe@list.vanderbilt.edu>
> > Sent: Tuesday, February 12, 2002 7:42 AM
> > Subject: RE: dose limits for members of the public
> >
> > > > I voted for 1000 mrem per year
> > >
> > > Jack,
> > >
> > > You seriously believe that members of the general public should be
allowed
> > to
> > > receive 1 rem/year above background and any dose from medical
procedures?
> >
> ------------------------------------------------------------------------
> > > Sandy Perle Tel:(714) 545-0100 / (800) 548-5100
> > > Director, Technical Extension 2306
> > > ICN Worldwide Dosimetry Service Fax:(714) 668-3149
> > > ICN Pharmaceuticals, Inc. E-Mail: sandyfl@earthlink.net
> > > ICN Plaza, 3300 Hyland Avenue E-Mail: sperle@icnpharm.com
> > > Costa Mesa, CA 92626
> > >
> > > Personal Website: http://sandy-travels.com
> > > ICN Worldwide Dosimetry Website: http://www.dosimetry.com
> > >
> > >
> > >
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