Low Dose Radiation Research Program - Basic Research

["Jacobus, John (OD/ORS)" <jacobusj@ors.od.nih.gov>]

The main site is http://www.sc.doe.gov/production/grants/Fr02-15.html



-- John 

John Jacobus, MS

Certified Health Physicist 

3050 Traymore Lane

Bowie, MD  20715-2024



E-mail:  jenday1@email.msn.com (H)      

****************

Department of Energy 



Office of Science Financial Assistance Program Notice 02-15; Low Dose

Radiation Research Program - Basic Research 



AGENCY: U.S. Department of Energy 



ACTION: Notice inviting grant applications. 



SUMMARY: The Office of Biological and Environmental Research (OBER) of the

Office of Science (SC), U.S. Department of Energy (DOE) and the Office of

Biological and Physical Research (OBPR), National Aeronautics and Space

Administration (NASA), hereby announce their interest in receiving grant

applications for well justified research that supports the DOE/OBER Low Dose

Radiation Research Program, and that may include complementary research of

direct interest to the NASA/OBPR Space Radiation Health Program that is of

sufficient scientific merit to qualify for partial NASA support. These

Programs use modern molecular tools to develop a better scientific basis for

understanding exposures and risks to humans from low dose and low fluence

radiation. 



Research areas of particular programmatic interest include: 



Endogenous oxidative damage versus low dose radiation-induced damage 

Radio-adaptive responses 

Bystander effects 

Individual genetic susceptibility to low dose radiation exposure 

Please review the Supplementary Information section below for further

discussion of programmatic needs. 



DATES: Preapplications (letters of intent) are strongly encouraged, but not

mandatory. A response to preapplications discussing the potential program

relevance of a formal application will be communicated within one week. 



The deadline for receipt of formal applications is 4:30 P.M., E.D.T, April

16, 2002, in order to be accepted for merit review and to permit timely

consideration for award in Fiscal Year 2002 and Fiscal Year 2003. 

. . .

Radio-Adaptive Response - The ability of a low dose of radiation to induce

cellular changes that alter the level of subsequent radiation-induced or

spontaneous damage. If low doses of radiation regularly and predictably

induce a protective response in cells exposed to subsequent low doses of

radiation or to spontaneous damage, this could have a substantial impact on

estimates of adverse health risk from low dose radiation. The generality and

the extent of the process of the induction itself need to be quantified, and

the responsible genes and proteins discovered. By "generality" is meant

quantification as a function of cell tissue type and species type; by

"extent" is meant quantification as a function of priming dose, dose rate,

and time constant of action. 

. . .







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