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RE: Ed Calabrese and Linda Baldwin again
Jim,
Actually I do since I read the paper. In case you haven't, I can send a pdf
file to you or others on this list who are interested in researching this
topic.
While it does lay out the argument that hormesis should be "new" host
factor, I think that it does not make the case for its use in setting
standards. My belief is that protection standards should be set to protect
all exposed, not just those with the least sensitive to the toxin. There
are obvious wide variation in responses. For example the study of six
cancer breast cell lines clearly shows a hormetic response in three lines,
but not the others, as shown in Figure 10. If you would set a limit of 0.2
mg/ml of suramin as a limit, the MCF-7 and Evas-T cell lines are really hit
hard by the exposure. I think that the dose response vs. age of rats in
Figure 6 for GABA and even the x-ray exposure responses in Figures 7 and 8
are important for public standards. When you are controlling the risk of
workers, you have the advantage of actually monitor their health through
employer mandated physical exams. However, for the general population,
children may be a greater risk. (Of course, this was obvious in the cases
of thyroid cancers among children after Chernobyl.
While hormesis can be demonstrated, I question its use as a factor in making
public health decisions.
Again, thanks for pointing our this article.
-- John
John Jacobus, MS
Certified Health Physicist
3050 Traymore Lane
Bowie, MD 20715-2024
E-mail: jenday1@email.msn.com (H)
-----Original Message-----
From: Muckerheide [mailto:muckerheide@attbi.com]
Sent: Monday, September 09, 2002 6:34 PM
To: Jacobus, John (OD/ORS); radsafe@list.vanderbilt.edu
Subject: Re: Ed Calabrese and Linda Baldwin again
John,
If you don't have anything to say, don't.
Perhaps if you'd read the paper you could address that instead.
. . .
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