Hormesis and regulatory limits

[Muckerheide <muckerheide@attbi.com>]

Friends, FYI.

 

Note in this ref that 18 pages of "discussion" follow the paper.

We can credit Ed Calabrese for the effort to apply the science to the

regulatory failure.

 

Please send comments if you review this paper and discussion, considering

the applicability of its principles to radiation protection.



Thank you.

Regards, Jim Muckerheide

Radiation, Science, and Health

===============================

 

> Hum Exp Toxicol 2002 Jul;21(7):385-9; discussion 391-408

> Implications of hormesis for industrial hygiene.

> 

> Jayjock MA, Lewis PG.

> Rohm and Haas Company, Spring House, Pennsylvania 19477, USA.

> rstmaj@rohmhaas.com

> 

> This paper considers hormesis as a valid and potentially valuable alternative

> hypothesis for low-dose response in the context of occupational health risk

> assessment. It outlines the current occupational risk assessment paradigm and

> its use of high-dose toxicological data in setting occupational exposure

> limits (OELs). This present effort is a call to science to investigate the

> potential promise of hormesis in providing prima facie experimental evidence

> for a low-dose threshold of toxic effect to chemical agents. The scientific

> effort and advancement advised in this piece could also lead to experimentally

> validated quantitative estimates of the toxic effect extant at occupational

> exposures in the region of the OEL.

> 

> http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_u

> ids=12269701&dopt=Abstract





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