Calabrese and Baldwin on hormesis in sensitive populations

[Muckerheide <muckerheide@attbi.com>]

Friends, FYI.



Our friends Ed Calabrese and Linda Baldwin have published the following

paper.



Regards, Jim Muckerheide

========================



> Regul Toxicol Pharmacol 2002 Jun;35(3):414

> 

> Hormesis and high-risk groups.

> 

> Calabrese E, Baldwin L.

> 

> The concept of hormesis (i.e., biological phenomena characterized by

> dose-response relationships displaying low-dose stimulation and high-dose

> inhibition) has important implications for current risk assessment practices

> because of its generalizability with respect to experimental model, agent, and

> endpoint measured. This paper addresses the question of whether hormesis is

> present in high-risk subpopulations and highly susceptible species. Evaluation

> of published data revealed that hormetic dose-response relationships occur

> with similar quantitative characteristics among species and individuals that

> display widely differing susceptibility to various toxicants. This observation

> suggests that the cause of the differential susceptibility in the more

> susceptible organisms is not due to the absence of the hormetic response but

> to some other factor(s). However, despite the recognition that hormetic

> responses are common and similar in susceptible and resistant organisms there

> are sufficient examples indicating that some strains/individuals may lack the

> capacity to produce the low-dose stimulatory response. Thus, the capacity to

> display hormetic effects is one of a variety of factors affecting differential

> susceptibility to xenobiotics and needs to be addressed within the hazard

> assessment process.



http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list

_uids=12202056&dopt=Abstract 



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