RE: Calabrese and Baldwin on hormesis in sensitive populations

["Jacobus, John (NIH/OD/ORS)" <jacobusj@ors.od.nih.gov>]

So, what this says is that since some individuals do not display a low-dose

stimulatory response, we need to take this into consideration when

developing regulations.  Are you suggesting that regulations should protect

the most sensitive individuals?  Aren't our regulations restrictive enough

for you?



-- John 



-----Original Message-----

From: Muckerheide [mailto:muckerheide@attbi.com]

Sent: Tuesday, October 01, 2002 7:33 AM

To: radsafe@list.vanderbilt.edu

Subject: Calabrese and Baldwin on hormesis in sensitive populations





Friends, FYI.



Our friends Ed Calabrese and Linda Baldwin have published the following

paper.



Regards, Jim Muckerheide

========================



> Regul Toxicol Pharmacol 2002 Jun;35(3):414

. . .

> to some other factor(s). However, despite the recognition that hormetic

> responses are common and similar in susceptible and resistant organisms

there

> are sufficient examples indicating that some strains/individuals may lack

the

> capacity to produce the low-dose stimulatory response. Thus, the capacity

to

> display hormetic effects is one of a variety of factors affecting

differential

> susceptibility to xenobiotics and needs to be addressed within the hazard

> assessment process.

. . .

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