Re: Calabrese and Baldwin on hormesis in sensitive populations

[Muckerheide <muckerheide@attbi.com>]

on 10/3/02 10:45 AM, Jacobus, John (NIH/OD/ORS) at jacobusj@ors.od.nih.gov

wrote:



> So, what this says is that since some individuals do not display a low-dose

> stimulatory response, we need to take this into consideration when

> developing regulations.  Are you suggesting that regulations should protect

> the most sensitive individuals?  Aren't our regulations restrictive enough

> for you?



Misread it again!? :-)

 

> -- John 

> 

> -----Original Message-----

> From: Muckerheide [mailto:muckerheide@attbi.com]

> Sent: Tuesday, October 01, 2002 7:33 AM

> To: radsafe@list.vanderbilt.edu

> Subject: Calabrese and Baldwin on hormesis in sensitive populations

> 

> 

> Friends, FYI.

> 

> Our friends Ed Calabrese and Linda Baldwin have published the following

> paper.

> 

> Regards, Jim Muckerheide

> ========================

> 

>> Regul Toxicol Pharmacol 2002 Jun;35(3):414

> . . .

>> to some other factor(s). However, despite the recognition that hormetic

>> responses are common and similar in susceptible and resistant organisms

> there

>> are sufficient examples indicating that some strains/individuals may lack

> the

>> capacity to produce the low-dose stimulatory response. Thus, the capacity

> to

>> display hormetic effects is one of a variety of factors affecting

> differential

>> susceptibility to xenobiotics and needs to be addressed within the hazard

>> assessment process.

> . . .

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