Hormesis in DSB formation and repair

[Muckerheide <muckerheide@attbi.com>]

Friends,



Further indication of hormetic effects in the dynamics of DSB formation and

repair by irradiation.



If you have access to this journal/article, I would appreciate your

contribution and review/comments.



Thank you.

Regards, Jim

============



Radiation Physics and Chemistry

Volume 65, Issues 4-5, November 2002, Pages 487-493



Molecular mechanisms and time-dependent dynamics of hormesis, antagonism and

radioprotective effects at combined ionizing irradiation of biological

systems 



Vladimir I. Vysotskii, , a, Anatolii A. Pinchuka, Alla A. Kornilovab and

Igor I. Samoylenkoc



Abstract

We study the time-dependent dynamics of formation, relaxation and

self-reparation of DNA double-strand breaks at combined irradiation and the

non-radiation degradation processes. The self-repairing process of DNA

double-strand breaks is related with the peculiarities of long-range

interaction of nucleotides within the breakage area. The properties of an

intracellular liquid and the characteristics of the long-range interaction

between the end pairs of nucleotides in the area of DNA double-strand break

are changed during irradiation. Each kind of irradiation is characterized by

certain effectiveness of double-strand breaks formation but on the other

hand, the irradiation creates the conditions for their liquidation. Based on

the analysis and correlation of these phenomena the time-dependent theory

for DNA degradation was created, including hormesis phenomenon, radiation

antagonism, the validity of anomaly influence of low and large doses at

sharp and chronic irradiation and other effects. A qualitative and

quantitative agreement of the theory and experimental results was obtained. 



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