Re: Hormesis in DSB formation and repair

[Muckerheide <muckerheide@attbi.com>]

on 11/11/02 1:06 AM, Bjorn Cedervall at bcradsafers@HOTMAIL.COM wrote:



>> Even if this were true, what's the point?

> 

> That with each DSB the cell statistically moves one step further into either

> towards genomic chaos or cell death.



You're not saying that the authors of this paper are considering misrepair

in their measure of "enhanced repair"?





> Bjorn Cedervall

> ----------------------

>>> Further indication of hormetic effects in the dynamics of DSB formation

> and repair by irradiation.

>> 

>> Much of mammalian repair of DSBs is actually misrepair (misrejoining) and

> information is lost in the cell.





And how much do you mean by "much?"



(And rad-induced DSBs are trivial in endogenous DSBs?)



Thanks,

Regards, Jim



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