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RE: Hormetic Effects of Radiation should not be limited to cancer
Ten years ago I did many experiments involving irradiation of cells in
culture. Here no immunesystem is active. Always I could detect hormetic
effects in survival of treated cells in the lower doses of irradiation.
Another possibile mechanism could be improved DNA repair under stress. Also
in the change from normalcells to cancercells in vivo, DNA-repair (or
misrepair) could play a vital role. I think research to the mechanism of
hormesis should not be limited to the immunesystem.
André Geerdink
>There are several studies that show radiation does
>lead to increases in various immune system markers.
>To me, however, is the relevance of the effect. For
>example, "The immunobiology of low-dose total-body
>irradiation: more questions than answers." Safwat A in
>Radiat Res. 2000 May;153(5 Pt 1):599-604.
>
>One problem in cancer treatment is that the body does
>not recognize the tumor as a "foreign" body to attack.
> An increased immune response may not lead to any
>beneficial effects.
>
>I am sure that there are those on those on this list
>who disagree, and they will hopefully provide some
>documentation of positive studies.
>
>--- goldinem@SONGS.SCE.COM wrote:
>
> >
> >
> >
> >
> > In the discussion of hormetic effects, some folks
> > say that "a low level of
> > radiological stress may stimulate the immune
> > system." Is there any
> > laboratory evidence to support such a claim? In
> > other words, any measure
> > of changes to hormones, immunoglobulin levels,
> > lymphocyte counts, tumor
> > suppressor increases,... anything that would
> > contribute to a beneficial
> > effect (that exceeds the downside)? The flip side
> > of the argument, that
> > low levels of radiological stress have a deleterious
> > effect, does have
> > support in molecular radiation biology and tissue
> > culture studies down to
> > pretty low levels.
> >
> > Have a good, long holiday weekend.
> > Eric M. Goldin
> > <goldinem@songs.sce.com>
> >
> >
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>
>=====
>+++++++++++++++++++
>"Everyone is ignorant, only on different subjects."
>Will Rogers
>
>-- John
>John Jacobus, MS
>Certified Health Physicist
>e-mail: crispy_bird@yahoo.com
>
>
>
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