RE: Hormetic Effects of Radiation should not be limited to cancer

[John Jacobus <crispy_bird@YAHOO.COM>]

I am sure that you could demonstrate a cellular

response to any stressor, e.g., irradiation, heat,

nutritional, or chemical.  I do not believe that

radiation is unique.  It's study is better financed. 

Of course, everyone on this list server will be better

informed about radiation effects, since this is its

focus.



--- andre geerdink <volkswagen181@hotmail.com> wrote:



> Ten years ago I did many experiments involving

> irradiation of cells in 

> culture. Here no immunesystem is active. Always I

> could detect hormetic 

> effects in survival of treated cells in the lower

> doses of irradiation.

> Another possibile mechanism could be improved DNA

> repair under stress. Also 

> in the change from normalcells to cancercells in

> vivo, DNA-repair (or 

> misrepair) could play a vital role. I think research

> to the mechanism of 

> hormesis should not be limited to the immunesystem.

> 

> André Geerdink

> 

> >There are several studies that show radiation does

> >lead to increases in various immune system markers.

> >To me, however, is the relevance of the effect. For

> >example, "The immunobiology of low-dose total-body

> >irradiation: more questions than answers." Safwat A

> in

> >Radiat Res. 2000 May;153(5 Pt 1):599-604.

> >

> >One problem in cancer treatment is that the body

> does

> >not recognize the tumor as a "foreign" body to

> attack.

> >  An increased immune response may not lead to any

> >beneficial effects.

> >

> >I am sure that there are those on those on this

> list

> >who disagree, and they will hopefully provide some

> >documentation of positive studies.

> >

> >--- goldinem@SONGS.SCE.COM wrote:

> >

> > >

> > >

> > >

> > >

> > > In the discussion of hormetic effects, some

> folks

> > > say that "a low level of

> > > radiological stress may stimulate the immune

> > > system." Is there any

> > > laboratory evidence to support such a claim?  In

> > > other words, any measure

> > > of changes to hormones, immunoglobulin levels,

> > > lymphocyte counts, tumor

> > > suppressor increases,... anything that would

> > > contribute to a beneficial

> > > effect (that exceeds the downside)?  The flip

> side

> > > of the argument, that

> > > low levels of radiological stress have a

> deleterious

> > > effect, does have

> > > support in molecular radiation biology and

> tissue

> > > culture studies down to

> > > pretty low levels.

> > >

> > > Have a good, long holiday weekend.

> > > Eric M. Goldin

> > > <goldinem@songs.sce.com>

> > >

> > >

>

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> >

> >=====

> >+++++++++++++++++++

> >"Everyone is ignorant, only on different subjects."

> >Will Rogers

> >

> >-- John

> >John Jacobus, MS

> >Certified Health Physicist

> >e-mail:  crispy_bird@yahoo.com

> >

> >

> >

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=====

+++++++++++++++++++

"Everyone is ignorant, only on different subjects."

Will Rogers



-- John

John Jacobus, MS

Certified Health Physicist

e-mail:  crispy_bird@yahoo.com





		

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