RE: Genetic Effects?

["Wright, Will \(DHS-PSB\)" <WWright2@DHS.CA.GOV>]

like i said, one would to do the classic genetic crosses and sequence where epigenic effects prevent mating experiments as we do in all other organisms. rest assured the mutations can occur. the sperm and egg situation is not exactly comprable to lower organism crosses due to the prior state of those two cell types thus avoiding an excessive load. the lab studies are done all the time and the cell line demonstrate the generational passage by a single cell.



-----Original Message-----

From: owner-radsafe@list.vanderbilt.edu

[mailto:owner-radsafe@list.vanderbilt.edu]On Behalf Of Russ Johnson

Sent: Tuesday, November 16, 2004 1:10 PM

To: Estabrooks, Bates (IHK); radsafe@list.Vanderbilt.Edu

Subject: Re: Genetic Effects?





As far as I know, the possibility exists but how would you obtain a viable

correlation? A big problem is that its too hard to separate out a

radiation-cause from all the other environmental contributors everyone is

exposed to 24-7, including the natural unspecific cancers and mutations that

occur naturally in any population. I suppose a controlled lab tissue study could

be done, but how does that extrapolate to the whole organism? Differences

between people, species, sexes, age, etc. etc. ? Does that point mutation

continue or does it wash out? How large is large, and what kind of radiation?

Mutations can likely be produced with tiny amounts, but in the right "spot". See

how complex it gets? With a very large dose, I would consider cell death as the

issue rather than mutations anyway. I would think this one is hard to call.

-Russ



"Estabrooks, Bates (IHK)" wrote:



> Radsafers,

>

> I imagine this topic has been worked over on this forum before, so I ask

> your forbearance as I pose this question.

>

> The Sep. 2004 issue of Science & Technology Review from LLNL includes a

> primer on radiation in a sidebar on p. 6.  In it, the following statement is

> made: "Exposure to large amounts of ionizing radiation (on the order of

> hundreds of times the natural exposure levels) increases the risk of. . .

> genetic mutations that can be passed on to future generations."

>

> Is there any evidence of this (genetic effects) in humans?

>

> Thanks.

>

> Bates Estabrooks

> BWXT Y-12

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