[ RadSafe ] Re: LDR extends lifespan, and immune competence (again, still)

[jjcohen]

FYI, a few years ago there was a string on radsafe on the possibility of administering supplementary radioactivity to those with "radiation deficiency" in order to achieve "optimal dosage". In discussing the best radionuclide for the purpose, as I recall, those that tend to concentrate in single organs such as the radioiodines should be avoided. I don't think any consensus was reached on what the "best" radionuclide should be, but because of its uniform distribution, tritium would seem to be a good bet.
  ----- Original Message ----- 
  From: yuan-chi luan 
  To: uniqueproducts at comcast.net 
  Cc: shliu at iner.gov.tw 
  Sent: Saturday, April 02, 2005 5:27 PM
  Subject: Re: LDR extends lifespan, and immune competence (again, still)


  Dear Dr. Caplan:

  I think any isotope might be ok, but should with long biohalf-live. Kondo ever analysed the dose in received by ever fisherman. There was a NUREG  by NRC about the atomic bomb workers internal contaminated, the doses might be able found.

  Y.C Luan
  ----------------------------------------------- originnal message--------------------------------------


  >From: "Jay Caplan" <uniqueproducts at comcast.net> 
  >Reply-To: "Jay Caplan" <uniqueproducts at comcast.net> 
  >To: "yuan-chi luan" <nbcsoc at hotmail.com> 
  >Subject: Re: LDR extends lifespan, and immune competence (again, still) 
  >Date: Sat, 2 Apr 2005 14:25:25 -0600 
  > 
  >Dr. Luan, 
  >Which isotope were you considering and dosage? 
  >Jay Caplan 
  >   ----- Original Message ----- 
  >   From: yuan-chi luan 
  >   To: kazsakai at criepi.denken.or.ip 
  >   Cc: wlchen at ym.edu.tw ; tisechou at hotmail.com ; wpdeng at ms41.hinet.net ; t5rgwjvs at mail.4797.com.tw ; htkung at ms79.hinet.net ; nusta66 at hotmail.com ; nbcsocmong at yahoo.com ; pual0401 at yahoo.com.tw ; hjren at iner.gov.tw ; mlshen at ccms.ntu.edu.tw ; mcshieh at so-net.net.tw ; wuj at aruplab.com ; johntm.wu at msa.hinet.net ; slyao at ms47.hinet.net ; jingying at ms22.hinet.net ; mbrexchange at list.ans.org ; bogen at llnl.gov ; edwardc at schoolph.umass.edu ; cdn-nucl-l at mailman1.cis.McMaster.CA ; nuc-en at ecolo.org ; pfong at physics.emory.edu ; higsond at bigpond.net.au ; indianjrr at yahoo.co.in ; nrer at obninsk.com ; cns at cnnc.com.cn ; liuxr at bine.com.cn ; luan2k03 at yahoo.com.cn ; andre.maisseu at wanadoo.fr ; rad-sci-l at WPI.EDU ; singer at sepp.org ; R.wakeford at bnfl.com ; shliu at iner.gov.tw 
  >   Sent: Saturday, April 02, 2005 1:50 PM 
  >   Subject: FW: LDR extends lifespan, and immune competence (again, still) 
  > 
  > 
  >   Dear Dr. Sakai: 
  > 
  >   You will remember Y.C. Luan when when you remember some one giving a Chinese dinner in Hawaii. 
  > 
  >    I am glad to see your paper again. Your paper in Hawaii showed the low-dose-rate irrdiation of mice could reduce their skin tumor,thymic lymphumas, diabetes and sever autoimmune disease really given me tremendous impression. Radiation is not harmful as ICRP espected 
  > 
  >   The low-dose-rate external radiation could immune a lot bad thing, I would like to give you a idea for you to think the possibility in testing with mice to have low-dose-rate of internal radiation by injection of some long-life radioactive isotope into the mice. The only trouble you have to treat the mice as radio-waste. The manhattan workers and the fishermen in  Lucky Dragon 5 had quite high internal contamination, but they are not 25% died in cancers, they  seemed to immunized. is it possibly to have immunization by injection? is it better to have immunity in the Co-60 contamianted apartments in Taiwan? 
  > 
  >   Please give regards to Dr. Hattori 
  > 
  >   Y.C. Luan 
  >   ----------------------------------------------- original  message-------------------------- 
  > 
  > 
  >   >From: "Muckerheide, James" <jimm at WPI.EDU> 
  >   >To: <rad-sci-l at WPI.EDU> 
  >   >Subject: LDR extends lifespan, and immune competence  (again, still) 
  >   >Date: Fri, 1 Apr 2005 11:41:00 -0500 
  >   > 
  >   >Friends, 
  >   > 
  >   >This paper is by our great friends Yasuhiro Ina and Kazuo Sakai at the CRIEPI 
  >   >Low Dose Radiation Research Center in Komae. 
  >   > 
  >   >I have not yet read the full paper. The journal contents may not yet be 
  >   >internet accessible.  Let me know if you need it for review when it is 
  >   >available (or perhaps request it from Yasuhiro or Kaz, though they may also 
  >   >be waiting for the final published version :-). 
  >   > 
  >   >Regards, Jim Muckerheide 
  >   >Radiation, Science, and Health 
  >   >===================== 
  >   > 
  >   >Ina, Y. and Sakai, K. 
  >   > 
  >   >Further Study of Prolongation of Life Span Associated with Immunological 
  >   >Modification by Chronic Low-Dose-Rate Irradiation in MRL-lpr/lpr Mice: 
  >   >Effects of Whole-Life Irradiation. 
  >   > 
  >   >Radiat. Res. 163, 418-423 (2005). 
  >   > 
  >   >MRL-lpr/lpr mice carry a deletion in the apoptosis-regulating Fas gene that 
  >   >markedly shortens life due to multiple severe diseases. In our previous study 
  >   >(Radiat. Res. 161, 168- 173, 2004), chronic low-dose-rate gamma irradiation 
  >   >of mice at 0.35 or 1.2 mGy/h for 5 weeks markedly prolonged the life span, 
  >   >accompanied by immunological activation. This report shows that extension of 
  >   >the irradiation period to the entire life of the mice at the same dose rates 
  >   >improved survival further. The 50% survival time for untreated mice, 134 
  >   >days, was prolonged to 502 days by 1.2 mGy/h life-long irradiation. Also 
  >   >obtained were a time course and a radiation dose-rate response for the 
  >   >activation of the immune system as indicated by a significant increase in 
  >   >CD4(+) CD8(+) T cells in the thymus and CD8(+) T cells in the spleen and also 
  >   >by a significant decrease in CD3(+) CD45R/B220(+) cells and CD45R/B220(+) 
  >   >CD40(+) cells in the spleen. Drastic ameliorations of multiple severe 
  >   >diseases, i.e. total-body lymphadenopathy, splenomegaly and serious 
  >   >autoimmune diseases including proteinuria, and kidney and brain-central 
  >   >nervous system syndromes, were found in parallel with these immunological 
  >   >activations, with lifelong low-dose-rate irradiation being more effective 
  >   >than 5-week irradiation at low dose rates. 
  >   > 
  >   >