[ RadSafe ] Cell inactivation by ionizing radiation

[John Jacobus]

For those really interested, see
http://www.iop.org/EJ/S/1/NNA408409/yFrM0KmBBEobXcQKjhSG3g/article/-alert=1462/0031-9155/50/7/007/pmb5_7_007.pdf

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Physics in Medicine and Biology
Volume 50, 7 April 2005
http://www.iop.org/EJ/toc/-alert=1462/0031-9155/50/7

    Probabilistic two-stage model of cell inactivation
by ionizing particles
    Pavel Kundra't, Milos Lokaji'cek and Hana
Hromci'kova'
    2005 Phys. Med. Biol. 50 1433-1447
    Abstract: 
http://www.iop.org/EJ/abstract/-alert=1462/0031-9155/50/7/007
    Full text PDF:
http://www.iop.org/EJ/article/-alert=1462/0031-9155/50/7/007/pmb5_7_007.pdf

    A model of biological effects of ionizing
particles, especially of protons and other ions, is
proposed. The model is based on distinguishing the
single-particle and collective effects of the
underlying radiobiological mechanism. The
probabilities of individual particles causing severe
damage to DNA, their synergetic or saturation
combinations, and the effect of the cellular repair
system are taken into account. The model enables one
to describe linear, parabolic and more complex curves,
including those exhibiting low-dose hypersensitivity
phenomena, in a systematic way. Global shape as well
as detailed structure of survival curves might be
represented, which is crucial if different
fractionation schemes in radiotherapy should be
assessed precisely. Experimental cell-survival data
for inactivation of V79 cells by low-energy protons
have been analysed and corresponding detailed
characteristics of the inactivation mechanism have
been derived for this case.


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"Embarrassed, obscure and feeble sentences are generally, if not always, the result of embarrassed, obscure and feeble thought."
Hugh Blair, 1783

-- John
John Jacobus, MS
Certified Health Physicist
e-mail:  crispy_bird at yahoo.com


		
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