Re: iodine uptake in thyroid

[Andy Hull <hull@mail.sep.bnl.gov>]

Andrew,
You may find some relevant information in

"Iodine Prophylaxis Following Nuclear Accidents", Edited by E. Rubery and
E. Smales, Proceedings of a joint WHO/CEC Workshop, July 1988. Published by
Pergamon Press 1990.

In particular, Section l covers normal thyroid function and the response to
iodine.

Andy Hull
EHSS-BNL
Upton, NY 11973
Ph.  516-344-4210

At 04:42 PM 4/14/98 -0500, you wrote:
>I'm looking for some information on the uptake of iodine in the thyroid 
>for adults (chronic exposures), more specifically, the relative or 
>fractional uptake of iodine when compared to the normal amount of iodine 
>ingested.  ICRP 56 uses the value of 0.3.  Dunning and Schwarz (Health 
>Phys 40 (5) 1981) provide estimates of the distribution of iodine uptake 
>which shows that the mean is 0.19, median 0.17, and the mode 0.15.  The 
>value of 0.3 probably represents about the 95% upper bound.  I'm 
>uncertain as to whether this value is appropriate for chronic exposures 
>to radioactive iodine (I-129) that represent anywhere from 50% to 200% of 
>the normal, daily requirements of iodine (roughly 150 ęg/d ingested -    
>30 ęg used (Guyton and Hall - Textbook of Medical Physiology)).  Could 
>the fractional uptake simply be estimated as the amount needed over the 
>amount ingested, i.e., does the body maintain the iodine concentration in 
>the body under homeostatic control?
>
>Any insight, references, etc., would be appreciated.
>
>
>
>Sincerely,
>Andrew H. Thatcher, MSHP, CHP
>Washington Department of Health
>360-236-3255 voice*
>360-236-2255 fax*
>dht0303@doh.wa.gov
>*new number
>
>
>