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RE: Abscopal effects on critical organs
An indirect route to this information might be the original MIRD documents on internal dosimetry. You would have to look at their assumptions but should be able to use the listed dosimetry data. A medical HP should have some information in this area also.
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From: H. G Claycamp[SMTP:hgc2+@pitt.edu]
Sent: Friday, October 16, 1998 10:30 AM
To: Multiple recipients of list
Subject: Re: Abscopal effects on critical organs
While I don't have a paper at my finger tips, I can recommend that you
search the 1950s-1960s literature. I recall a number of papers (that were
history even when I read them) dealing with abscopal effects.
Good hunting.
-Gregg hgc2+@pitt.edu
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
H. Gregg Claycamp, Ph.D., C.H.P.
Assoc. Prof. and Assoc. Chair
Dept. of Environmental and
Occupational Health
University of Pittsburgh
412-967-6524 FAX: 412-624-1020
On Thu, 15 Oct 1998, Dave Abbott wrote:
> Hello Radsafers:
>
> I've been working on a project that involves predicting the quantities of
> airborne radionuclides that it would take to produce an acute lethality
> within 60 days. This involves estimating how much immersion and inhalation
> it would take to produce a lethal dose to the bone marrow, small intestine,
> and lungs. The calculations have included cross talk, i.e., transport of
> photons from noncritical organs to critical organs. A reviewer insists
> that this approach is flawed because it doesn't take into account indirect
> effects. Direct effects on a noncritical organ will influence the lethal
> dose on the critical organs. I have been unable to find any data to
> substantiate or refute this abscopal effect on lethal doses. Can anyone
> shed some light on this question, preferably with citations in available.
>
> Thanks,
> David Abbott
> Lawrence Livermore National Laboratory
> abbott@washops.llnl.gov
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