Re: cellular radiosensitivity

["Gibbs, S Julian" <s.julian.gibbs@vanderbilt.edu>]

The D-zero (that's D-sub-0) of most mammalian cells, 
including human, in culture,is about 1.5 Gy (range 1-2 Gy). 
This includes fibroblasts.  Limited data indicate that 
this applies also to these cells in vivo.  The end point is 
reproductive cell death, i.e., permanent loss of clonogenic 
capacity.  The D-zero for lymphocytes is about 0.7 Gy. This 
applies to low-LET radiation, i.e., x or gamma, or 
electrons.  See Hall, Radiobiology for the Radiologist, ed 
4, Lippincott, 1994.

***********************************************************
S. Julian Gibbs, DDS, PhD               Voice: 615-322-3190
Professor of Radiology                    FAX: 615-322-3764 
Dept. of Radiology & Radiological Sciences
Vanderbilt University Medical Center
Nashville TN 37232-2670        Email:j.gibbs@vanderbilt.edu
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Power corrupts.  Absolute power is kind of neat.
                                   --Anonymous

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