Re: DTPA

["Jim Ogden" <James.Ogden@tdh.state.tx.us>]

Date:          Thu, 2 Sep 1999 07:41:21 -0500 (CDT)
Reply-to:     Scott.Osborn@rfets.gov
Subject:    DTPA

Scott:  

Contact your local nuclear pharmacy and ask for preparation inserts 
for DTPA from their "Product Information".  Best choices in your area 
would by Syncor International Corp., Mallinckrodt, or Medi-Physics.

My latest catalog lists 6  different "kits" for preparation of DTPA 
lists the following ADVERSE REACTIONS:
1. Pyrogenic and allergic reactions to Tc-99m Pentetate injection 
preparations have been reported in literature.
2.  No long term animal studies have been performed to evaluate 
carcinogenic potential or whether Tc-99m Pentetate injection affects 
fertility in males and females.  Mutigenesis studies have not been 
conducted.
3.. Animal reproduction and tetratpgenecity studies have not been 
conducted with Tc-99m pentetate injection.  It is also not known 
whether Tc-99m pentetate injection can cause fetal harm when 
administered to a pregnant woman or can affect the reproductive 
capacity.  There have been no studies in pregnant women.  Tc-99m 
pentetate should be given to a pregnant woman only if clearly needed.
4.  Tc-99m is excreted in human milk during lactation.  Therefore, 
formula should be substituted for breast feedings.
5. Pediatric Use:  Safety and effectiveness in children have not been 
established.

These are general and contained in all literature I currently have 
for DTPA.

Thanks,

 

James H. Ogden, Jr., Incident Investigator
Emergency Response and 
   Incident Investigation
INTERNET Address (james.ogden@tdh.state.tx.us)
(512) 834-6688 ext 2027
(512) 834-6654 FAX

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