rna mutation repair

["Charp, Paul" <pac4@cdc.gov>]

Andy -- there are quite a few books, peer-reviewed papers, etc. on nucleic
acid repair in general.  An older text but still very good is Arther (?)
Kornberg's book entitled DNA Synthesis.  More recent papers can usually be
found in Radiation Research and cell/molecular biology journals.

In general you will find that RNA based organisms (if you consider a virus,
the ultimate parasite, an organism) do have the repair mechanisms very
similar to the DNA based organisms.  This includes the specialize DNA
polymerases that contain the exonuclease, endonuclease systems.

hope this helps

Paul A. Charp, Ph.D.
CDC/ATSDR
Senior Health Physicist
Division of Health Assessment and Consultation
Federal Facilities Assessment Branch
1600 Clifton Rd (E-56)
Atlanta, Georgia 30333
(404) 639-6004, fax 6075


Date: Fri, 3 Sep 1999 14:11:17 -0400 
From: "Karam, Andrew" <Andrew_Karam@URMC.Rochester.edu>
To: "'Radsafe'" <radsafe@romulus.ehs.uiuc.edu>
Subject: RNA mutation repair
Message-ID:
<D3CB9FB020BDD211B83300A0C9E9754A01356C6D@exmc2.urmc.rochester.edu>

Dear Radsafers,

I have another question to pose to you, quite off the topic of recent
postings.  I am trying to learn about mutation repair in RNA and RNA-based
organisms.  This is for an independent study project that is part of my
graduate work.  I would greatly appreciate any references anyone in
Radsafe-land could provide as a starting point.

Thanks!

Andy

Andrew Karam, CHP              (716) 275-1473 (voice)
Radiation Safety Officer          (716) 275-3781 (office)
University of Rochester           (716) 256-0365 (fax)
601 Elmwood Ave. Box HPH   Rochester, NY  14642

Andrew_Karam@URMC.Rochester.edu
http://Intranet.urmc.rochester.edu/RadiationSafety

There is no Chase so pleasant, methinks, as to drive a Thought, by good
conduct, from one end of the World to the other; and never to lose sight of
it till it fall into Eternity, where all things are lost as to our
knowledge.  T. Burnet, The Theory of the Earth, 1697

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