Re: incorporation measurements

[carol marcus <csmarcus@ucla.edu>]

At 03:46 PM 10/26/99 -0500, you wrote:
>Carol Marcus wrote:
>
>"THERE ARE NO DATA INDICATING A
>PROBLEM.  As nuclear medicine has been practiced in this country for 63
>years, I think that that's enough time to construct a data base.  NONE EXISTS."
>
>
>I would agree with Carol and add the following:  I have worked for a radio-
>pharmaceutical MANUFACTURER for over 20 years, and the largest internal 
>exposure we have seen in that time has been due to inhalation of airborne
>Mo-99 particulates after a loss of negative pressure on a hot cell back in
>the 80's.  The committed effective dose was about 1 mSv (100 mrem).
>
>Yes, our production staff submit urine bioassays on a weekly basis, due to 
>the high activity throughput (100s of GBq up to 100s of TBq per week, 
>depending on radionuclide), but we could easily justify discontinuing them
>due to the rarity and insignificance of intakes.
>
>Finally, the intake limits on most radiopharmaceutical radionuclides are
>so high that if there were any significant intake, the worker would detect
>a problem during routine contamination frisking.
>
>For a more rigorous approach to deciding when to require some kind of bioassay,
>take a look at ANSI 13.14-1983, "Internal dosimetry programs for tritium
>exposure- minimum requirements", which provides guidance on when to require
>bioassays based on activity levels, degree of volatility, and containment
>level.  You can use this same approach for other radionuclides if you 
>adjust for radiotoxicity (e.g. the ratio of ALIs) and relative volatility.
>
>Hope this helps.
>
>John Laferriere, CHP
>DuPont Pharmaceuticals Co.
>Medical Imaging Division
>john.r.laferriere@dupontpharma.com
>
>
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Dear John:

Thanks much for your information and advice.

Ciao, Carol

Carol S. Marcus, Ph.D., M.D.
<csmarcus@ucla.edu>

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