PubMed Cheriyan99 RadRes - Kerala newborn cytogenetics

[Jim Muckerheide <jmuckerheide@delphi.com>]

Friends,

Further data on cytogenetic studies in newborns in low- vs hi-dose areas
of Kerala that contradict the LNT.

Regards, Jim Muckerheide 
Radiation, Science, and Health 
muckerheide@mediaone.net 
==============================

Radiat Res 1999 Dec;152(6 Suppl):S154-8 

 Genetic monitoring of the human population from high-level natural
radiation areas of Kerala on the southwest coast of India:  II.
Incidence of numerical and structural chromosomal aberrations in the
lymphocytes of newborns. 

 Cheriyan VD, Kurien CJ, Das B, Ramachandran EN, Karuppasamy CV, Thampi
MV, George KP, Kesavan PC, Koya PK, Chauhan PS 

 Monazite Survey Project, Bhabha Atomic Research Centre, Trombay
Mumbai-400 84085, India.
 [Medline record in process]

 Cytogenetic studies using cord blood samples from newborns from
high-level natural radiation areas of the Kerala coast in Southwest
India have been in progress since 1986. A total of 963,940 metaphases
from 10,230 newborns have been screened for various types of chromosomal
aberrations. Comparison of 8,493 newborns (804,212 cells) from
high-level natural radiation areas (dose rate >1.5 mGy/year) and 1,737
newborns (159,728 cells) from normal-level natural radiation areas
(</=1.5 mGy/year) did not show any significant difference in the
frequency of dicentrics, translocations, inversions or other types of
aberrations known to be associated with radiation exposure. The
cytogenetic studies were continued for constitutional anomalies using
karyotype analysis, and scoring of 16,169 newborns has been completed.
The overall frequency of constitutional anomalies was 4.95 +/- 0.55 per
1,000 newborns, which is comparable to the incidence reported in the
literature. Within the limitations of sample size, the frequencies of
total autosomal and sex aneuploids as well as structural anomalies were
comparable between the high-level and normal-level natural radiation
areas. A striking observation was the presence of rogue cells, the
rarely occurring metaphases with a high level of chromosomal damage,
which have not been reported previously among newborns.
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