[ RadSafe ] Re: Fwd: Re: Hormesis mechanisms in vivo

John Jacobus crispy_bird at yahoo.com
Thu Nov 3 16:40:24 CST 2005

Why did you send this to me?  Are you claiming that
radiation can be used against allergies from pollen
and ragweed?  That certain is a new claim?  Do you
have any proof of this?

--- howard long <hflong at pacbell.net> wrote:

> howard long <hflong at pacbell.net> wrote:Date: Thu, 3
> Nov 2005 11:12:00 -0800 (PST)
> From: howard long <hflong at pacbell.net>
> Subject: Re: Hormesis mechanisms in vivo
> To: "Ludwig E. Feinendegen" <feinendegen at gmx.net>,
> "Muckerheide, James" <jimm at WPI.EDU>,
> "rad-sci-l at wpi.edu" <rad-sci-l at WPI.EDU>
> Allergy Treatmant Uses Hormesis.
> All physicians who use desensitization for allergy,
> use hormesis.
> We inject miniscule, increasing doses twice weekly
> of the same antigens (like pollen)
> which cause inflammation on application to skin
> scratch.
> Asthma and hayfever when found to be from a specific
> antigen (like walnut pollen in my case)
> are markedly relieved by this treatment, standard
> for half a century.
> With LNT, one would expect slight worsening of
> symptoms like wheeze or watery eyes,
> when low dose of the toxin is applied.
> Hormesis, not LNT, is the usual biologic response to
> toxins like radiation and pollen.
> Beir 7 procamation of LNT is like, "Flat earth!" 
> Treat its advocates accordingly.
> Howard Long
>  <feinendegen at gmx.net> wrote:
> st1\:* {	BEHAVIOR: url(#default#ieooui)}Thanks, Jim.
> This is another encouraging paper and puts our work
> into broader perspectives.  All the best, Ludwig
> ----- Original Message ----- 
> From: Muckerheide, James 
> To: rad-sci-l at wpi.edu 
> Sent: Thursday, October 27, 2005 5:00 PM
> Subject: Hormesis mechanisms in vivo
> Friends,
> This further indicates a consistent response between
> chemical and radiation exposures, further
> establishing ‘hormesis’ as a fundamental principle
> in biology.
> I do not have access to this journal.
> Regards, Jim Muckerheide
> ===================
> Cancer Lett. 2005 Oct 21; [Epub ahead of print]
> Alpha-benzene hexachloride exerts hormesis in
> preneoplastic lesion formation of rat
> hepatocarcinogenesis with the possible role for
> hepatic detoxifying enzymes.
> Puatanachokchai R, Morimura K, Wanibuchi H, Oka M,
> Kinoshita A, Mitsuru F, Yamaguchi S, Funae Y,
> Fukushima S
> Department of Pathology, Osaka City University
> Medical School, Abeno-ku, Asahi-machi 1-4-3, Osaka
> 545-8585, Japan.
> Recently there has been a shift in the prevailing
> paradigm regarding the dose dependence of carcinogen
> action with increasing acceptance of hormesis
> phenomenon, although underlying mechanisms remain to
> be established. To ascertain whether alpha-benzene
> hexachloride (alpha-BHC) might act by hormesis, rats
> were initiated with diethylnitrosamine and then
> alpha-BHC ranging from 0.01 to 500 ppm was
> administered in the diet for 10 weeks. The highest
> concentration of alpha-BHC significantly increased
> the number and area of glutathione S-transferase
> placental form (GST-P) positive foci, preneoplastic
> lesions in the liver, but its low! dose, 0.05ppm,
> caused significant reduction, showing a J-shape
> dose-response curve. The proliferating cell nuclear
> antigen positive index for GST-P positive foci in
> the low dose-treated group was significantly
> reduced. The dose response curves of CYP450 content,
> NADPH-P450 reductase activity and
> 8-hydroxydeoxyguanosine formation revealed the same
> pattern as
>  GST-P positive foci data. The response curves of
> CYP2B1 and 3A2 in their activities, protein and mRNA
> expression showed a threshold but CYP2C11 activity
> exhibited an inverted J-shape. These results might
> suggest the possibility of hormesis of alpha-BHC at
> early stages of rat hepatocarcinogenesis. The
> possible mechanism involves induction of detoxifying
> enzymes at low dose, influencing free radical
> production and oxidative stress, and consequently
> pathological change in the liver.

On Oct. 5, 1947, in the first televised White House address, President Truman asked Americans to refrain from eating meat on Tuesdays and poultry on Thursdays to help stockpile grain for starving people in Europe. 

-- John
John Jacobus, MS
Certified Health Physicist
e-mail:  crispy_bird at yahoo.com

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