[ RadSafe ] Universal Hormesis mechanisms in vivo?

howard long hflong at pacbell.net
Thu Nov 3 17:48:58 CST 2005

Allergy shots (very low dose of antigens known to be poison to that person)
like low dose alpha-benzene hydrochloride (below, even sounds toxic),
like low dose ionizing radiation (the subject of this site)
demonstrate that hormesis is universal in biology,
Beir 7 LNT propagandists should be treated like persons perpetuating flat-earth dogma.
I am not aware of the effect of LDR on asthma. 
Maybe Pat Lewis of Health Mines (radon) has anecdotes. 
She is looking for a study there.
Howard Long  

John Jacobus <crispy_bird at yahoo.com> wrote:
Why did you send this to me? Are you claiming that
radiation can be used against allergies from pollen
and ragweed? That certain is a new claim? Do you
have any proof of this?

--- howard long wrote:

> howard long wrote:Date: Thu, 3
> Nov 2005 11:12:00 -0800 (PST)
> From: howard long 
> Subject: Re: Hormesis mechanisms in vivo
> To: "Ludwig E. Feinendegen" ,
> "Muckerheide, James" ,
> "rad-sci-l at wpi.edu" 
> Allergy Treatmant Uses Hormesis.
> All physicians who use desensitization for allergy,
> use hormesis.
> We inject miniscule, increasing doses twice weekly
> of the same antigens (like pollen)
> which cause inflammation on application to skin
> scratch.
> Asthma and hayfever when found to be from a specific
> antigen (like walnut pollen in my case)
> are markedly relieved by this treatment, standard
> for half a century.
> With LNT, one would expect slight worsening of
> symptoms like wheeze or watery eyes,
> when low dose of the toxin is applied.
> Hormesis, not LNT, is the usual biologic response to
> toxins like radiation and pollen.
> Beir 7 procamation of LNT is like, "Flat earth!" 
> Treat its advocates accordingly.
> Howard Long
> wrote:
> st1\:* { BEHAVIOR: url(#default#ieooui)}Thanks, Jim.
> This is another encouraging paper and puts our work
> into broader perspectives. All the best, Ludwig
> ----- Original Message ----- 
> From: Muckerheide, James 
> To: rad-sci-l at wpi.edu 
> Sent: Thursday, October 27, 2005 5:00 PM
> Subject: Hormesis mechanisms in vivo
> Friends,
> This further indicates a consistent response between
> chemical and radiation exposures, further
> establishing ‘hormesis’ as a fundamental principle
> in biology.
> I do not have access to this journal.
> Regards, Jim Muckerheide
> ===================
> Cancer Lett. 2005 Oct 21; [Epub ahead of print]
> Alpha-benzene hexachloride exerts hormesis in
> preneoplastic lesion formation of rat
> hepatocarcinogenesis with the possible role for
> hepatic detoxifying enzymes.
> Puatanachokchai R, Morimura K, Wanibuchi H, Oka M,
> Kinoshita A, Mitsuru F, Yamaguchi S, Funae Y,
> Fukushima S
> Department of Pathology, Osaka City University
> Medical School, Abeno-ku, Asahi-machi 1-4-3, Osaka
> 545-8585, Japan.
> Recently there has been a shift in the prevailing
> paradigm regarding the dose dependence of carcinogen
> action with increasing acceptance of hormesis
> phenomenon, although underlying mechanisms remain to
> be established. To ascertain whether alpha-benzene
> hexachloride (alpha-BHC) might act by hormesis, rats
> were initiated with diethylnitrosamine and then
> alpha-BHC ranging from 0.01 to 500 ppm was
> administered in the diet for 10 weeks. The highest
> concentration of alpha-BHC significantly increased
> the number and area of glutathione S-transferase
> placental form (GST-P) positive foci, preneoplastic
> lesions in the liver, but its low! dose, 0.05ppm,
> caused significant reduction, showing a J-shape
> dose-response curve. The proliferating cell nuclear
> antigen positive index for GST-P positive foci in
> the low dose-treated group was significantly
> reduced. The dose response curves of CYP450 content,
> NADPH-P450 reductase activity and
> 8-hydroxydeoxyguanosine formation revealed the same
> pattern as
> GST-P positive foci data. The response curves of
> CYP2B1 and 3A2 in their activities, protein and mRNA
> expression showed a threshold but CYP2C11 activity
> exhibited an inverted J-shape. These results might
> suggest the possibility of hormesis of alpha-BHC at
> early stages of rat hepatocarcinogenesis. The
> possible mechanism involves induction of detoxifying
> enzymes at low dose, influencing free radical
> production and oxidative stress, and consequently
> pathological change in the liver.

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