[ RadSafe ] Re: Universal Hormesis mechanisms in vivo?

[John Jacobus]

Howard,
Antigens are biological and alpha-benzene
hydrochloride is a chemical.  Ionizing radiation is a
form of energy.  The response may not be the same.

I assumed that you knew the differences.  By the way,
you do know about the placebo effect?

--- howard long <hflong at pacbell.net> wrote:

> Allergy shots (very low dose of antigens known to be
> poison to that person)
> like low dose alpha-benzene hydrochloride (below,
> even sounds toxic),
> like low dose ionizing radiation (the subject of
> this site)
> demonstrate that hormesis is universal in biology,
> NOT LNT!
>  
> Beir 7 LNT propagandists should be treated like
> persons perpetuating flat-earth dogma.
>  
> I am not aware of the effect of LDR on asthma. 
> Maybe Pat Lewis of Health Mines (radon) has
> anecdotes. 
> She is looking for a study there.
>  
> Howard Long  
> 
> John Jacobus <crispy_bird at yahoo.com> wrote:
> Howard,
> Why did you send this to me? Are you claiming that
> radiation can be used against allergies from pollen
> and ragweed? That certain is a new claim? Do you
> have any proof of this?
> 
> --- howard long wrote:
> 
> > 
> > 
> > howard long wrote:Date: Thu, 3
> > Nov 2005 11:12:00 -0800 (PST)
> > From: howard long 
> > Subject: Re: Hormesis mechanisms in vivo
> > To: "Ludwig E. Feinendegen" ,
> > "Muckerheide, James" ,
> > "rad-sci-l at wpi.edu" 
> > 
> > Allergy Treatmant Uses Hormesis.
> > 
> > All physicians who use desensitization for
> allergy,
> > use hormesis.
> > We inject miniscule, increasing doses twice weekly
> > of the same antigens (like pollen)
> > which cause inflammation on application to skin
> > scratch.
> > 
> > Asthma and hayfever when found to be from a
> specific
> > antigen (like walnut pollen in my case)
> > are markedly relieved by this treatment, standard
> > for half a century.
> > 
> > With LNT, one would expect slight worsening of
> > symptoms like wheeze or watery eyes,
> > when low dose of the toxin is applied.
> > Hormesis, not LNT, is the usual biologic response
> to
> > toxins like radiation and pollen.
> > Beir 7 procamation of LNT is like, "Flat earth!" 
> > Treat its advocates accordingly.
> > 
> > Howard Long
> > 
> > 
> > wrote:
> > st1\:* { BEHAVIOR: url(#default#ieooui)}Thanks,
> Jim.
> > This is another encouraging paper and puts our
> work
> > into broader perspectives. All the best, Ludwig
> > ----- Original Message ----- 
> > From: Muckerheide, James 
> > To: rad-sci-l at wpi.edu 
> > Sent: Thursday, October 27, 2005 5:00 PM
> > Subject: Hormesis mechanisms in vivo
> > 
> > 
> > 
> > Friends,
> > 
> > 
> > 
> > This further indicates a consistent response
> between
> > chemical and radiation exposures, further
> > establishing ‘hormesis’ as a fundamental principle
> > in biology.
> > 
> > 
> > 
> > I do not have access to this journal.
> > 
> > 
> > 
> > Regards, Jim Muckerheide
> > 
> > ===================
> > 
> > 
> > 
> > Cancer Lett. 2005 Oct 21; [Epub ahead of print]
> > 
> > 
> > 
> > Alpha-benzene hexachloride exerts hormesis in
> > preneoplastic lesion formation of rat
> > hepatocarcinogenesis with the possible role for
> > hepatic detoxifying enzymes.
> > 
> > Puatanachokchai R, Morimura K, Wanibuchi H, Oka M,
> > Kinoshita A, Mitsuru F, Yamaguchi S, Funae Y,
> > Fukushima S
> > 
> > Department of Pathology, Osaka City University
> > Medical School, Abeno-ku, Asahi-machi 1-4-3, Osaka
> > 545-8585, Japan.
> > 
> > Recently there has been a shift in the prevailing
> > paradigm regarding the dose dependence of
> carcinogen
> > action with increasing acceptance of hormesis
> > phenomenon, although underlying mechanisms remain
> to
> > be established. To ascertain whether alpha-benzene
> > hexachloride (alpha-BHC) might act by hormesis,
> rats
> > were initiated with diethylnitrosamine and then
> > alpha-BHC ranging from 0.01 to 500 ppm was
> > administered in the diet for 10 weeks. The highest
> > concentration of alpha-BHC significantly increased
> > the number and area of glutathione S-transferase
> > placental form (GST-P) positive foci,
> preneoplastic
> > lesions in the liver, but its low! dose, 0.05ppm,
> > caused significant reduction, showing a J-shape
> > dose-response curve. The proliferating cell
> nuclear
> > antigen positive index for GST-P positive foci in
> > the low dose-treated group was significantly
> > reduced. The dose response curves of CYP450
> content,
> > NADPH-P450 reductase activity and
> > 8-hydroxydeoxyguanosine formation revealed the
> same
> > pattern as
> > GST-P positive foci data. The response curves of
> > CYP2B1 and 3A2 in their activities, protein and
> mRNA
> > expression showed a threshold but CYP2C11 activity
> > exhibited an inverted J-shape. These results might
> > suggest the possibility of hormesis of alpha-BHC
> at
> > early stages of rat hepatocarcinogenesis. The
> > possible mechanism involves induction of
> detoxifying
> > enzymes at low dose, influencing free radical
> > production and oxidative stress, and consequently
> > pathological change in the liver.
> >


+++++++++++++++++++
On Oct. 5, 1947, in the first televised White House address, President Truman asked Americans to refrain from eating meat on Tuesdays and poultry on Thursdays to help stockpile grain for starving people in Europe. 

-- John
John Jacobus, MS
Certified Health Physicist
e-mail:  crispy_bird at yahoo.com


	
		
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