[ RadSafe ] Re: Universal Hormesis mechanisms in vivo?

Fri Nov 4 12:58:29 CST 2005

Hi John,

You are right, but this relates to the point we've been making for 10 years
or so:  The biological responses to stresses are intrinsic to biology.  

Stress response is not unique to each stressor.  The stress protein HSP70
(heat shock protein) is stimulated in many cases.  It is also shown to apply
to heat, and exercise, and to many psychological stresses, and to heavy
metals, etc., etc.

It would be unlikely (or unbelievable) if biology responded differently to
radiation, with stimulation at low doses and suppression at high doses.  (Not
all suppression is "bad," e.g., heavy exercise in the damage-repair regime,
and not all stimulation is "good."  But we know that the specific responses
to radiation are generally a net-positive effect on the biological and
physiological functions of an organism - and why cellular studies are
generally irrelevant to understand low vs. high dose effects to an organism,
even though it may be informative about (some) mechanisms.)

It is also the case that the stimulation of specific genes, proteins,
enzymes, and effects on immune cells, etc. are entirely DIFFERENT when
exposed to a low dose vs. a high dose.  In some cases the response at a low
dose is stimulated vs. suppressed, or the opposite; and in some cases totally
different genes are stimulated at high vs. low doses.  This means that a
biological "linearity" isn't possible, with responses 'similar' but reduced
at low vs. high doses.  Biological and physiological responses are entirely
different in immunological whole organisms at low vs. high doses. 

Remember Murphy (PNAS 1920) stimulating vs. suppressing lymphocytes at lower
vs. higher doses? Causing dramatic decreases instead of increases of cancers
vs. controls:
http://cnts.wpi.edu/rsh/DD3/Murphy20PNASResistMiceCa!.pdf 
(just a couple of pages).

Regards, Jim 

> -----Original Message-----
> From: radsafe-bounces at radlab.nl [mailto:radsafe-bounces at radlab.nl] On
> Behalf Of John Jacobus
> Sent: Friday, November 04, 2005 1:28 PM
> To: howard long
> Cc: radsafe; rad-sci-l at WPI.EDU
> Subject: [ RadSafe ] Re: Universal Hormesis mechanisms in vivo?
> 
> Howard,
> Antigens are biological and alpha-benzene
> hydrochloride is a chemical.  Ionizing radiation is a
> form of energy.  The response may not be the same.
> 
> I assumed that you knew the differences.  By the way,
> you do know about the placebo effect?
> 
> --- howard long <hflong at pacbell.net> wrote:
> 
> > Allergy shots (very low dose of antigens known to be
> > poison to that person)
> > like low dose alpha-benzene hydrochloride (below,
> > even sounds toxic),
> > like low dose ionizing radiation (the subject of
> > this site)
> > demonstrate that hormesis is universal in biology,
> > NOT LNT!
> >
> > Beir 7 LNT propagandists should be treated like
> > persons perpetuating flat-earth dogma.
> >
> > I am not aware of the effect of LDR on asthma.
> > Maybe Pat Lewis of Health Mines (radon) has
> > anecdotes.
> > She is looking for a study there.
> >
> > Howard Long
> >
> > John Jacobus <crispy_bird at yahoo.com> wrote:
> > Howard,
> > Why did you send this to me? Are you claiming that
> > radiation can be used against allergies from pollen
> > and ragweed? That certain is a new claim? Do you
> > have any proof of this?
> >
> > --- howard long wrote:
> >
> > >
> > >
> > > howard long wrote:Date: Thu, 3
> > > Nov 2005 11:12:00 -0800 (PST)
> > > From: howard long
> > > Subject: Re: Hormesis mechanisms in vivo
> > > To: "Ludwig E. Feinendegen" ,
> > > "Muckerheide, James" ,
> > > "rad-sci-l at wpi.edu"
> > >
> > > Allergy Treatmant Uses Hormesis.
> > >
> > > All physicians who use desensitization for
> > allergy,
> > > use hormesis.
> > > We inject miniscule, increasing doses twice weekly
> > > of the same antigens (like pollen)
> > > which cause inflammation on application to skin
> > > scratch.
> > >
> > > Asthma and hayfever when found to be from a
> > specific
> > > antigen (like walnut pollen in my case)
> > > are markedly relieved by this treatment, standard
> > > for half a century.
> > >
> > > With LNT, one would expect slight worsening of
> > > symptoms like wheeze or watery eyes,
> > > when low dose of the toxin is applied.
> > > Hormesis, not LNT, is the usual biologic response
> > to
> > > toxins like radiation and pollen.
> > > Beir 7 procamation of LNT is like, "Flat earth!"
> > > Treat its advocates accordingly.
> > >
> > > Howard Long
> > >
> > >
> > > wrote:
> > > st1\:* { BEHAVIOR: url(#default#ieooui)}Thanks,
> > Jim.
> > > This is another encouraging paper and puts our
> > work
> > > into broader perspectives. All the best, Ludwig
> > > ----- Original Message -----
> > > From: Muckerheide, James
> > > To: rad-sci-l at wpi.edu
> > > Sent: Thursday, October 27, 2005 5:00 PM
> > > Subject: Hormesis mechanisms in vivo
> > >
> > >
> > >
> > > Friends,
> > >
> > >
> > >
> > > This further indicates a consistent response
> > between
> > > chemical and radiation exposures, further
> > > establishing 'hormesis' as a fundamental principle
> > > in biology.
> > >
> > >
> > >
> > > I do not have access to this journal.
> > >
> > >
> > >
> > > Regards, Jim Muckerheide
> > >
> > > ===================
> > >
> > >
> > >
> > > Cancer Lett. 2005 Oct 21; [Epub ahead of print]
> > >
> > >
> > >
> > > Alpha-benzene hexachloride exerts hormesis in
> > > preneoplastic lesion formation of rat
> > > hepatocarcinogenesis with the possible role for
> > > hepatic detoxifying enzymes.
> > >
> > > Puatanachokchai R, Morimura K, Wanibuchi H, Oka M,
> > > Kinoshita A, Mitsuru F, Yamaguchi S, Funae Y,
> > > Fukushima S
> > >
> > > Department of Pathology, Osaka City University
> > > Medical School, Abeno-ku, Asahi-machi 1-4-3, Osaka
> > > 545-8585, Japan.
> > >
> > > Recently there has been a shift in the prevailing
> > > paradigm regarding the dose dependence of
> > carcinogen
> > > action with increasing acceptance of hormesis
> > > phenomenon, although underlying mechanisms remain
> > to
> > > be established. To ascertain whether alpha-benzene
> > > hexachloride (alpha-BHC) might act by hormesis,
> > rats
> > > were initiated with diethylnitrosamine and then
> > > alpha-BHC ranging from 0.01 to 500 ppm was
> > > administered in the diet for 10 weeks. The highest
> > > concentration of alpha-BHC significantly increased
> > > the number and area of glutathione S-transferase
> > > placental form (GST-P) positive foci,
> > preneoplastic
> > > lesions in the liver, but its low! dose, 0.05ppm,
> > > caused significant reduction, showing a J-shape
> > > dose-response curve. The proliferating cell
> > nuclear
> > > antigen positive index for GST-P positive foci in
> > > the low dose-treated group was significantly
> > > reduced. The dose response curves of CYP450
> > content,
> > > NADPH-P450 reductase activity and
> > > 8-hydroxydeoxyguanosine formation revealed the
> > same
> > > pattern as
> > > GST-P positive foci data. The response curves of
> > > CYP2B1 and 3A2 in their activities, protein and
> > mRNA
> > > expression showed a threshold but CYP2C11 activity
> > > exhibited an inverted J-shape. These results might
> > > suggest the possibility of hormesis of alpha-BHC
> > at
> > > early stages of rat hepatocarcinogenesis. The
> > > possible mechanism involves induction of
> > detoxifying
> > > enzymes at low dose, influencing free radical
> > > production and oxidative stress, and consequently
> > > pathological change in the liver.
> > >
> 
> 
> +++++++++++++++++++
> On Oct. 5, 1947, in the first televised White House address, President
> Truman asked Americans to refrain from eating meat on Tuesdays and poultry
> on Thursdays to help stockpile grain for starving people in Europe.
> 
> -- John
> John Jacobus, MS
> Certified Health Physicist
> e-mail:  crispy_bird at yahoo.com
> 
> 
> 
> 
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