AW: [ RadSafe ] dose RATE is the decisive variable

[Rainer.Facius at dlr.de]

Dear Prof. Raabe:

Thank you for that reminder (and the boost to my literacy :-). Though you apparently detected the ramifications of this fundamental principle quite some time ago, this time the data pertain directly to human cancer mortality (which of course I would expect to display the same regularities). Incidentally, Gregoire&Cleland cite two of the articles in your list:

 

Raabe, O.G. (1987) Three-dimensional dose-response models of competing risks and natural life span. Fundamental and Applied Toxicology 8: 465 473.
.... 
Raabe, O.G. (1994) Three-Dimensional Models of Risk from Internally Deposited Radionuclides, Chapter 30, pp. 663-656 in Internal Radiation Dosimetry (O.G. Raabe, Ed.), Medical Physics Publishing, Madison, WI.


I would appreciate to receive (electronic) copies of as many of the papers from your list as you have available.

Thank you in advance and best regards, Rainer

Dr. Rainer Facius
German Aerospace Center
Institute of Aerospace Medicine
Linder Hoehe
51147 Koeln
GERMANY
Voice: +49 2203 601 3147 or 3150
FAX:   +49 2203 61970



________________________________

Von: Otto Raabe [mailto:ograabe at ucdavis.edu]
Gesendet: Fr 01.09.2006 23:58
An: Facius, Rainer; radsafe at radlab.nl
Betreff: Re: [ RadSafe ] dose RATE is the decisive variable



At 02:54 AM 9/1/2006, Rainer.Facius at dlr.de wrote:


	The recent paper elaborates a seemingly trivial principle, i.e., the response of (not only nonlinear) systems capable of intrinsic counteractive measures to compensate external stimuli is not primarily determined by the stimulus' amplitude but rather by the ratio between the stimulus' temporal gradient and the characteristic 'response' time of the system's feed-back control systems - as long as its capacities are not overstrained. Thus the rate is not a parameter - as conventionally it is conceived of - but a primary independent variable. 

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September 1, 2006

I have shown in several studies and reported in several publications that dose rate and time were the primary variables affecting cancer induction, and that cumulative dose is an unreliable indicator of cancer risk.


.... 


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Prof. Otto G. Raabe, Ph.D., CHP
Center for Health & the Environment
University of California
One Shields Avenue
Davis, CA 95616
E-Mail: ograabe at ucdavis.edu
Phone: (530) 752-7754   FAX: (530) 758-6140
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