[ RadSafe ] Re: [FIREBASEVOICE] The Depleted Uranium Con Game Continues
Roger Helbig
rhelbig at california.com
Tue Aug 7 03:51:18 CDT 2007
Treasure trove of what? And why is that no one reads the massive amount of information already on the net -- there is the Royal Society; there is the UN Environmental Programme and of course there is the Great Satan itself, the Department of Defense, which of course is hiding everything so that's why they have hundreds of pages of reports, tests, etc. going back to the 1950s. No, it's all hidden, just like Agent Orange .. now, there was really a culprit in that one, Monsanto Corp did lie about the nature of Agent Orange, but the only ones who have ever lied about DU are Saddam Hussein, Slobadan Milosevich and the Far Far Left along with the con artists who decided that they needed scare veterans and their families in order to bankrupt the country testing for a non-existent problem. Well, Denise, what is the reason why a Registered Nurse has fallen for this?
There is zero evidence that the cancer data has anything to do with DU. There is far more evidence to show that these cancer statistics have absolutely nothing to do with DU.
RADSAFErs -- there is a lengthy list of cites assembled by Ms Denise Nichols who served as a Nurse in Desert Storm and has a sincere interest in veterans health. What say you about this lengthy list of cites; how many of them are really germane?
Roger Helbig
Reading this extensive list of citations makes it seem like the new con game is the funding of research projects that will not really solve the problem
----- Original Message -----
From: <wndbear at aol.com>
To: <firebasevoice at yahoogroups.com>
Cc: <DSNurse at aol.com>
Sent: Monday, August 06, 2007 9:52 PM
Subject: [FIREBASEVOICE] ATTN: FIREBASE VOICE GROUP MEMBERS
Denise has a literal treasure trove of information concerning DU (all of
which Roger seems to ignore). As she sends more, I'll send it through to the
Firebase Voice Group. Anyone desiring to keep a "library" of this
information, please do! It may be needed again soon, as our ranks increase.
Lord willing, our Vets of the ongoing wars will need a "home" .... "Firebase
Voice" needs to welcome them with open arms. As we Vietnam era vets begin
to die off (in case you're not aware, we are now the "senior citizens" of
Veterans!), hopefully they will follow in our footsteps, as we fight for our
rights.
WELCOME HOME .........
Steve Mungie
_Wndbear at aol.com_ (mailto:Wndbear at aol.com)
Any suggestions that can be offered to improve the Firebase Voice, or the
Firebase Network, please forward them to me ASAP .... and visit our website at
_www.firebasenetwork,net_ (http://www.firebasenetwork,net)
------------------------------------------------------------------------------
-----------------------------------------------------------------------
Some more on DU .......................
In a message dated 8/6/2007 10:24:44 A.M. Central America Standard T,
DSNurse writes:
GULF WAR VETERANS CANCER DATA
DATA FROM 1991-1994
A: THYROID CANCER MORTALITY DATA 1991-1994
FACTS: Thyroid Carcinoma occurs in less than 5% of nodules
INCIDENCE: 26,000/YR OR 10 PER 100,000
EXPECTED DEATH: 1500/YR OR 0.5/100,000
OVERALL CURE RATE IS HIGH
ACTUAL GULF WAR VETERAN DEATHS FROM THYROID CANCER BY YEAR
1991---0
1992 ---3 (2 <25 YEARS OLD)
1993 ---4 (1<25YRS; 1 25-34YRS; 2 35-44YRS)
1994---9 (4<25YRS; 3 25-34YRS; 3 35-44YRS)
NOTE STATS EXPECTED IN 18-34 YR GROUP IS 0.1 PER 100,000 FOR 600,000 WOULD
BE 0.6
RESULTS
FOR THYROID CARCINOMA MORTALITY RATE FOR THE GULF WAR VETERANS LESS THAN 25
YR OLD IS 4.0. THIS IS 4 TIMES THE EXPECTED DEATH RATE FOR THIS CANCER IN
THIS AGE GROUP.
DEATH RATE
FOR <25 YR OLD : 25 OR LESS CASES/YR PER 300,000,000
1.0 TO 1.5 PER 10 MILLION
4 ½ DEATHS WOULD BE EXPECTED IN POPULATION OF 30,000,000
GULF WAR POPULATION 600,000
ODDS RATIO 0.000011 STATISTICALLY SIGNIFICANT
B. TESTICULAR CARCINOMA FACTS
RARE DISEASE 5,500 NEW CASES/YR
OVERALL INCIDENCE 1.5-2.0/100,000
RARE DISEASE < 2/100,000
Highest Age Specific 20-34 yr
DEATHS 0.2/100,000 or 1.2/600,000
MORTALITY TESTICULAR CANCER GULF WAR VETERANS
1991 2 (1 IN 18-24 YR; 1 IN 25-34 YR)
1992 16 (6 IN 18-24 YR; 5 IN 25-34 YR, 5 IN 35-44 YR)
1993 63 (18 IN 18-24 YR; 38 in 25-34 YR; 7 in 35-44 Yr)
1994 43 (11 in 18-24 YR; 32 in 25-34 Yr)
Note: Expected Number of Deaths for yrs 1991-94 would be 30/600,000
Mortality Testicular Cancer Gulf War Veterans By Year
1993 shows 2.1 times the expected death rate
1994 shows 1.45 times the expected death rate.
Testicular Cancer Mortality By Age Gulf War Veterans
1991 1in 25-34 age group expected 1.2
1992 5 in 25-34 age group 4 times expected
1993 total 16-- 5<25; 10 (25-34); 1 (35-49) 13 times expected
1994 total 11 still over 9 times expected
C. LEUKEMIA INFORMATION
Disease of white blood cells. Abnormally high number of white cells are
produced by the bone marrow and lymphatic tissues.
Over the last 30 years, research has shown that 95% of patients with
leukemia have an acquired genetic defect. The defect is a translocation (one piece
of genetic material moved to another piece of genetic material). The general
divisions of leukemia are dependent upon the type of cells that are
proliferating. The cell types are lymphocytes and myelocytes. Each type of
leukemia, lymphocytic and myeloid is divided into acute and chronic.
Acute lymphoctic leukemia is a disease of the young and old. 75% of cases
of acute lymphocytic leukemia(ALL) occur in those younger than 15 years of
age. Chronic lymphocytic leukemia (CLL) accounts for 10,000 new cases per year.
The number of new cases of ALL are 4,000 per year. Thus 1,000 cases of ALL
are among adults. A fascinating aspect of ALL disease is the age
distribution in adults.
It has been observed that of the adults, (1,000) per year, there is an age
distribution. Of the occurrence of ALL.
In the Less than 25 age group, only 2% of 1,000 adults have ALL
In the 25 to 34 age group, 5% of 1000 adults.
In the 35 to 65 age group, 85% of 1,000 with ALL is seen
At 1,000 adult cases of ALL per year, ALL in adults becomes a RARE Disease
0.3 to 0.5 per 100,000 or 3.0 per 600,00.
Number of Cases of ALL for Persian Gulf Veterans
1992 1
1993 12
1994 13
THUS FOR 1993 and 1994, THE NUMBER OF ALL IS FOUR (4) TIMES THAN EXPECTED.
NUMBER OF DEATHS
>From ALL and CML is more than expected. There are 15,000 deaths from ALL
per year. For a population of 600,000, 3 deaths are expected.
For ALL the years 1991 to 1994, the Persian gulf death rate is 3.0. For
CML, the number of expected deaths is 850 per population or 2 per 600,000. In
1993, the number of deaths from CML was nine(9) and for 1994, the number of
deaths was seven(7). Thus, in 1994 the number of deaths from CML is 3-4 times
expected.
Myeloid Leukemia
Primarily a disease of the elderly. Myeloid leukemia is divided in acute
and chronic. In chronic myeloid leukemia, 5,000 new cases are expected per year
Age distribution is
Less than 25 2% of 5,000 or 0.3/600,000
25 to 34 age 10% of 5,000 or 1.0/600,000
35 to 44 age 11% of 5,000 or 1.0/600,000
45 and over 75% of 5,000
CML
One case per 600,000 is expected for adult CML in the less than 25 age group
and one case per 600,000 is expected in adults with CML in the 25-34 age
group.
Persian Gulf Group
1992 11 cases (under 25), 6 cases (25 to 34), 2 cases (35 to 44)
1993 7 cases (under 25), 10 cases (25-34), 3 cases (35-44)
1994 2 cases (under 25). 0 cases(25-34), 0 cases(35 to 44)
PERSIAN GULF INCIDENCE CML
Results: The incidence of CML in the Persian Gulf Group is 6-10 TIMES THE
EXPECTED RATE IN THE UNDER 44 AGE GROUP.
____________________________________
Get a sneak peek of the all-new _AOL.com_
(http://discover.aol.com/memed/aolcom30tour/?ncid=AOLAOF00020000000982) .
1: _Toxicol Sci._ (javascript:AL_get(this, 'jour', 'Toxicol Sci.');) 2007
Aug;98(2):458-68. Epub 2007 Jun 12.
(http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17566059&db=pubmed&url=http://tox
sci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17566059) _Links_
(javascript:PopUpMenu2_Set(Menu17566059);)
Modifications of inflammatory pathways in rat intestine following chronic
ingestion of depleted uranium.
_Dublineau I_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Dublineau%20I"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Results
Panel.Pubmed_RVAbstractPlus) , _Grandcolas L_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Grandcolas%20L"[Author]&itool=EntrezSyst
em2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) , _Grison S_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Grison%20S"
[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstr
actPlus) , _Baudelin C_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Baudelin%20C"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubme
d_ResultsPanel.Pubmed_RVAbstractPlus) , _Paquet F_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Paquet%20F"[Author]&itool=EntrezSys
tem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) , _Voisin P_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Voisin%20P
"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbst
ractPlus) , _Aigueperse J_ (http://www.ncbi.nlm.nih.gov/sites/entr
ez?Db=pubmed&Cmd=Search&Term="Aigueperse%20J"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.
Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) , _Gourmelon P_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Gourmelon%20P"[Author]&itoo
l=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) .
IRSN, Direction de la RadioProtection de l'Homme, Service de Radiobiologie
et d'Epidémiologie, Laboratoire de Radiotoxicologie expérimentale, F-92262
FONTENAY-aux-ROSES CEDEX, France.
The environmental contamination by dispersion of depleted uranium (DU) might
result in its chronic ingestion of DU by local populations. The aim of this
study was to determine if chronic ingestion of DU at low doses induces
inflammatory reactions in intestine, first biological system exposed to uranium
after ingestion. Experiments were performed with rats receiving uranium in
drinking water (40 mg/l) during 3, 6, or 9 months. Several parameters referring to
prostaglandin, histamine, cytokine, and nitric oxide (NO) pathways were
assessed in ileum. Concerning the prostaglandin pathway, a twofold increase in
gene expression of cyclooxygenase of type 2 was noted after 6 months, with no
changes in prostaglandins levels. At the same time, a decrease in mast cell
number was observed without any changes in histamine levels. Experiments on
cytokines showed increased gene expression of interleukin (IL)-1beta and IL-10
at 6 months, and decreased messenger RNA level of CCL-2. This change was
associated with decreased macrophage density. An opposite effect of DU was induced
on neutrophils, since increased number was observed at 3 (x1.7) and 9 months
(x3). The results obtained on NO pathway seemed to indicate that DU exposure
inhibited this pathway (decreased endothelial NO synthase messenger RNA,
inductive NO synthase activity and NO(2)(-)/NO(3)(-) levels) at 6 months. In
conclusion, this study demonstrated that chronic ingestion of DU-induced
time-dependent modifications of inflammatory pathways, notably in terms of immune
cell content. The ultimate effects of DU contamination might be pathogenic by
suppressing defense mechanisms or inducing hypersensitivity. Further
experiments should be thus performed to determine real consequences on intestinal
response to oral antigens.
PMID: 17566059 [PubMed - in process]
_Biochim Biophys Acta._ (javascript:AL_get(this, 'jour', 'Biochim Biophys
Acta.');) 2007 Feb;1770(2):266-72. Epub 2006 Oct 19.
(http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17118558&db=pubm
ed&url=http://linkinghub.elsevier.com/retrieve/pii/S0304-4165(06)00305-9)
_Links_ (javascript:PopUpMenu2_Set(Menu17118558);)
In vivo effects of chronic contamination with depleted uranium on vitamin D3
metabolism in rat.
_Tissandié E_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Tissandié%20E"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Results
Panel.Pubmed_RVAbstractPlus) , _Guéguen Y_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Guéguen%20Y"[Author]&itool=EntrezSystem2.PE
ntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) , _Lobaccaro JM_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Lobaccaro%20J
M"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbs
tractPlus) , _Grandcolas L_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Grandcolas%20L"[Author]&itool=EntrezSystem2.PEntrez.Pubmed
.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) , _Voisin P_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Voisin%20P"[Author]&itool=Ent
rezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) ,
_Aigueperse J_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Aigueperse%20J"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel
.Pubmed_RVAbstractPlus) , _Gourmelon P_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Sea
rch&Term="Gourmelon%20P"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) , _Souidi M_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Souidi%20M"[Author
]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus
) .
Institute for Radiological Protection and Nuclear Safety, Radiological
Protection and Human health Division, Radiobiology and Epidemiology Department,
Laboratory of Experimental Toxicology, BP no. 17, F-92262 Fontenay-aux-Roses
CEDEX, France.
The extensive use of depleted uranium (DU) in today's society results in the
increase of the number of human population exposed to this radionuclide. The
aim of this work was to investigate in vivo the effects of a chronic
exposure to DU on vitamin D(3) metabolism, a hormone essential in mineral and bone
homeostasis. The experiments were carried out in rats after a chronic
contamination for 9 months by DU through drinking water at 40 mg/L (1 mg/rat/day).
This dose corresponds to the double of highest concentration found naturally in
Finland. In DU-exposed rats, the active vitamin D (1,25(OH)(2)D(3)) plasma
level was significantly decreased. In kidney, a decreased gene expression was
observed for cyp24a1, as well as for vdr and rxralpha, the principal
regulators of CYP24A1. Similarly, mRNA levels of vitamin D target genes ecac1,
cabp-d28k and ncx-1, involved in renal calcium transport were decreased in kidney.
In the brain lower levels of messengers were observed for cyp27a1 as well as
for lxrbeta, involved in its regulation. In conclusion, this study showed for
the first time that DU affects both the vitamin D active form
(1,25(OH)(2)D(3)) level and the vitamin D receptor expression, and consequently could
modulate the expression of cyp24a1 and vitamin D target genes involved in calcium
homeostasis.
PMID: 17118558 [PubMed - indexed for MEDLINE]
____________________________________
Get a sneak peek of the all-new _AOL.com_
(http://discover.aol.com/memed/aolcom30tour/?ncid=AOLAOF00020000000982) .
1: _Toxicol Sci._ (javascript:AL_get(this, 'jour', 'Toxicol Sci.');) 2007
Aug;98(2):458-68. Epub 2007 Jun 12.
(http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=17566059&db=pubmed&url=http://tox
sci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17566059) _Links_
(javascript:PopUpMenu2_Set(Menu17566059);)
Modifications of inflammatory pathways in rat intestine following chronic
ingestion of depleted uranium.
_Dublineau I_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Dublineau%20I"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Results
Panel.Pubmed_RVAbstractPlus) , _Grandcolas L_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Grandcolas%20L"[Author]&itool=EntrezSyst
em2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) , _Grison S_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Grison%20S"
[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstr
actPlus) , _Baudelin C_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Baudelin%20C"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubme
d_ResultsPanel.Pubmed_RVAbstractPlus) , _Paquet F_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Paquet%20F"[Author]&itool=Entr
ezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) , _Voisin P_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Voisin%20P
"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbst
ractPlus) , _Aigueperse J_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Aigueperse%20J"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.
Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) , _Gourmelon P_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Gourmelon%20P"[Author]&itoo
l=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) .
IRSN, Direction de la RadioProtection de l'Homme, Service de Radiobiologie
et d'Epidémiologie, Laboratoire de Radiotoxicologie expérimentale, F-92262
FONTENAY-aux-ROSES CEDEX, France.
The environmental contamination by dispersion of depleted uranium (DU) might
result in its chronic ingestion of DU by local populations. The aim of this
study was to determine if chronic ingestion of DU at low doses induces
inflammatory reactions in intestine, first biological system exposed to uranium
after ingestion. Experiments were performed with rats receiving uranium in
drinking water (40 mg/l) during 3, 6, or 9 months. Several parameters referring to
prostaglandin, histamine, cytokine, and nitric oxide (NO) pathways were
assessed in ileum. Concerning the prostaglandin pathway, a twofold increase in
gene expression of cyclooxygenase of type 2 was noted after 6 months, with no
changes in prostaglandins levels. At the same time, a decrease in mast cell
number was observed without any changes in histamine levels. Experiments on
cytokines showed increased gene expression of interleukin (IL)-1beta and IL-10
at 6 months, and decreased messenger RNA level of CCL-2. This change was
associated with decreased macrophage density. An opposite effect of DU was induced
on neutrophils, since increased number was observed at 3 (x1.7) and 9 months
(x3). The results obtained on NO pathway seemed to indicate that DU exposure
inhibited this pathway (decreased endothelial NO synthase messenger RNA,
inductive NO synthase activity and NO(2)(-)/NO(3)(-) levels) at 6 months. In
conclusion, this study demonstrated that chronic ingestion of DU-induced
time-dependent modifications of inflammatory pathways, notably in terms of immune
cell content. The ultimate effects of DU contamination might be pathogenic by
suppressing defense mechanisms or inducing hypersensitivity. Further
experiments should be thus performed to determine real consequences on intestinal
response to oral antigens.
PMID: 17566059 [PubMed - in process]
_Biochim Biophys Acta._ (javascript:AL_get(this, 'jour', 'Biochim Biophys
Acta.');) 2007 Feb;1770(2):266-72. Epub 2006 Oct 19.
(http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17118558&db=pubm
ed&url=http://linkinghub.elsevier.com/retrieve/pii/S0304-4165(06)00305-9)
_Links_ (javascript:PopUpMenu2_Set(Menu17118558);)
In vivo effects of chronic contamination with depleted uranium on vitamin D3
metabolism in rat.
_Tissandié E_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Tissandié%20E"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Results
Panel.Pubmed_RVAbstractPlus) , _Guéguen Y_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Guéguen%20Y"[Author]&itool=EntrezSystem2.PE
ntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) , _Lobaccaro JM_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Lobaccaro%20J
M"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbs
tractPlus) , _Grandcolas L_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Grandcolas%20L"[Author]&itool=EntrezSystem2.PEntrez.Pubmed
.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) , _Voisin P_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Voisin%20P"[Author]&itool=Ent
rezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) ,
_Aigueperse J_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Aigueperse%20J"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel
.Pubmed_RVAbstractPlus) , _Gourmelon P_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Gourmelon%20P"[Author]&itool=EntrezSystem2.PEn
trez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus) , _Souidi M_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Souidi%20M"[Author
]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus
) .
Institute for Radiological Protection and Nuclear Safety, Radiological
Protection and Human health Division, Radiobiology and Epidemiology Department,
Laboratory of Experimental Toxicology, BP no. 17, F-92262 Fontenay-aux-Roses
CEDEX, France.
The extensive use of depleted uranium (DU) in today's society results in the
increase of the number of human population exposed to this radionuclide. The
aim of this work was to investigate in vivo the effects of a chronic
exposure to DU on vitamin D(3) metabolism, a hormone essential in mineral and bone
homeostasis. The experiments were carried out in rats after a chronic
contamination for 9 months by DU through drinking water at 40 mg/L (1 mg/rat/day).
This dose corresponds to the double of highest concentration found naturally in
Finland. In DU-exposed rats, the active vitamin D (1,25(OH)(2)D(3)) plasma
level was significantly decreased. In kidney, a decreased gene expression was
observed for cyp24a1, as well as for vdr and rxralpha, the principal
regulators of CYP24A1. Similarly, mRNA levels of vitamin D target genes ecac1,
cabp-d28k and ncx-1, involved in renal calcium transport were decreased in kidney.
In the brain lower levels of messengers were observed for cyp27a1 as well as
for lxrbeta, involved in its regulation. In conclusion, this study showed for
the first time that DU affects both the vitamin D active form
(1,25(OH)(2)D(3)) level and the vitamin D receptor expression, and consequently could
modulate the expression of cyp24a1 and vitamin D target genes involved in calcium
homeostasis.
PMID: 17118558 [PubMed - indexed for MEDLINE]
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