AW: [ RadSafe ] Tolerance doses

[Bjorn Cedervall]

Oops - tolerance dose is an old idea so that is a separate topic.

The TD as used in the clinical context is another topic and stands for therapeutic dose (I apologize for the corresponding remark in my previous mail).

 

I will probably come back to the old use of "tolerance dose" - didn't have time to check that during the weekend. The old use of "tolerance dose" may go back to the time before the year 1910 or so but began to be questioned in the 1930:ies. Questioning was probably not only because of Müller's observation on fruit flies but also because of low-doserate (but high total doses) observations relating to tissue damage (non-stochastic effects). I will not send any reference/publication in Swedish as the publications were in English (or possibly French) - I read this stuff in 1975 so please forgive me for not promptly remembering the details.
 

My personal comment only,

 

Bjorn Cedervall

-----------------------------------------------------------------------
> From: franz.schoenhofer at chello.at
> To: nils_rudqvist at hotmail.com; radsafe at radlab.nl
> Subject: AW: [ RadSafe ] Tolerance doses
> Date: Sun, 26 Apr 2009 15:53:03 +0200
> CC: 
> 
> Sorry to reveal my ignorance on RADSAFE - what is a "tolerance dose"??? We
> have maximal permissible doses, average ones, we have doses for radiation
> workers, for members of the public - so what else to confuse the radiation
> protection community? 
> 
> Could you please enlighten me, what a "tolerance dose" is. Eftersom jag
> talar flytande svenska far du skicka mig vilken svensk publikation som
> helst!
> 
> Best regards - med vänlig hälsning!
> 
> Franz
> 
> Franz Schoenhofer, PhD
> MinRat i.R.
> Habicherg. 31/7
> A-1160 Wien/Vienna
> AUSTRIA
> 
> 
> -----Ursprüngliche Nachricht-----
> Von: radsafe-bounces at radlab.nl [mailto:radsafe-bounces at radlab.nl] Im Auftrag
> von Nils Rudqvist
> Gesendet: Freitag, 24. April 2009 09:55
> An: radsafe at radlab.nl
> Betreff: [ RadSafe ] Tolerance doses
> 
> Dear colleagues,
> 
> I am writing a review article regarding tolerance doses and biological
> effects from radiation (with concepts as TD, MTD, MTA, NTCP, BED etc), but i
> have some problems in finding the right articles. My thought was to try to
> collect and relate the tolerance doses from different radiation methods,
> i.e. external and different radioisotopes used for internal therapy. I have
> done the usual searches but it seems to me that I either gets alot of hits
> or very few. 
> 
> Mainly, the organs of interest is kidney, liver and bone marrow. If you have
> any information or know where i can find the information needed, help would
> be much appreciated. Data from humans, mice or rats is favorable but if you
> have any data that you think might help me, please contact me.
> 
> Thanks,
> 
> Nils Rudqvist (nils.rudqvist at radfys.gu.se
> 
> Researcher at the Sahlgren Academy
> Gothenburg
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