[ RadSafe ] Two interesting papers on DNA repair mechanisms

blreider at aol.com blreider at aol.com
Fri Jul 2 07:45:27 CDT 2010

Parathasarathy & Rad Safe Group:

Thank you for posting these articles they are quite interesting.  It has long (>35 years) been hypothecized that the process to repair of DNA causes mutations, this is not a new concept.  I guess the next step is to identify the incorrect DNA sequence that initiates cancer cell formation.

The fact that there is a mechanism that accounts for double strand breaks being more frequently incorrectly repaired should be of  interest with regard to high LET radiations such as alpha as well as very high doses of low LET radiation even to a portion of the body.  What should the Quality Factors and RBEs be for very high doses of low LET radiation to a small region?  Depends upon the tissue and the volume irradiated I should think.  Do or will we need to rethink the Quality Factors and RBEs for high LET radiation based on new information regarding disease induction mechanisms?

Barbara Reider, CHP

-----Original Message-----
From: parthasarathy k s <ksparth at yahoo.co.uk>
To: radsafe <radsafe at health.phys.iit.edu>
Sent: Fri, Jul 2, 2010 7:56 am
Subject: [ RadSafe ] Two interesting papers on DNA repair mechanisms


he following papers just published reveal the complexities of  the DNA repair 

NA mutation rates raise curtain on cause of cancer
ttp://www.eurekalert.org/pub_releases/2010-07/bu-dmr063010.php >

cientists uncover novel role for DNA repair protein linked to cancer
 http://www.eurekalert.org/pub_releases/2010-07/tu-sun063010.php >

he finding that the process of repairing DNA damage itself causes more 
s worrying. No wonder one may have to continue to accept LNT concept for the 
ime being as a precautionary approach.
Any comments?


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