[ RadSafe ] Two interesting papers on DNA repair mechanisms

parthasarathy k s ksparth at yahoo.co.uk
Fri Jul 2 08:30:06 CDT 2010

Ms.Barbara Reider,

As you rightly explained there are interesting ramifications to the observations 
on DNA repair mechanisms. Let us how others react to these papers.


From: "blreider at aol.com" <blreider at aol.com>
To: ksparth at yahoo.co.uk; radsafe at health.phys.iit.edu
Sent: Fri, 2 July, 2010 18:15:27
Subject: Re: [ RadSafe ] Two interesting papers on DNA repair mechanisms

Parathasarathy & Rad Safe Group:

Thank you for posting these articles they are quite interesting.  It has long 
(>35 years) been hypothecized that the process to repair of DNA causes 
mutations, this is not a new concept.  I guess the next step is to identify the 
incorrect DNA sequence that initiates cancer cell formation.
The fact that there is a mechanism that accounts for double strand breaks being 
more frequently incorrectly repaired should be of  interest with regard to high 
LET radiations such as alpha as well as very high doses of low LET radiation 
even to a portion of the body.  What should the Quality Factors and RBEs be for 
very high doses of low LET radiation to a small region?  Depends upon the tissue 
and the volume irradiated I should think.  Do or will we need to rethink 
the Quality Factors and RBEs for high LET radiation based on new 
information regarding disease induction mechanisms?
Barbara Reider, CHP


-----Original Message-----
From: parthasarathy k s <ksparth at yahoo.co.uk>
To: radsafe <radsafe at health.phys.iit.edu>
Sent: Fri, Jul 2, 2010 7:56 am
Subject: [ RadSafe ] Two interesting papers on DNA repair mechanisms


The following papers just published reveal the complexities of  the DNA repair 

DNA mutation rates raise curtain on cause of cancer
http://www.eurekalert.org/pub_releases/2010-07/bu-dmr063010.php >

Scientists uncover novel role for DNA repair protein linked to cancer
< http://www.eurekalert.org/pub_releases/2010-07/tu-sun063010.php >

The finding that the process of repairing DNA damage itself causes more 
is worrying. No wonder one may have to continue to accept LNT concept for the 
time being as a precautionary approach.

Any comments?


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