[ RadSafe ] Cl-36 in Nuclear Medicine?

[David Derenzo]

I know I am jumping in a little late here, but Cl-36 is no longer  
available commercially.  And even when it was available, it would have  
been very costly to obtain a significant quantity.  I was used  
primarily in in-vitro research for ion transport studies in gut  
tissues.  Now that it is unavailable, I-125 is being used as a  
substitute.

Dave Derenzo
Hines VA Radiation Safety Officer


On Jul 16, 2010, at 11:47 AM, Vernig, Peter G. wrote:

> Gary,
>
> I was not aware of the 0.01% but IMO that might as well be 0.  You'd  
> have to give such a high dose to take advantage and then you have  
> all those regular betas.  I just can't see it.
>
> Any opinions in this e-mail are solely those of the author, and are  
> not represented as those of the VA Eastern Colorado HCS, the Dept.  
> of Veterans Affairs, or the US Government.
>
> Peter G. Vernig,RSO
>
>
> -----Original Message-----
> From: radsafe-bounces at health.phys.iit.edu [mailto:radsafe-bounces at health.phys.iit.edu 
> ] On Behalf Of Cary Renquist
> Sent: Friday, July 16, 2010 10:43 AM
> To: radsafe at health.phys.iit.edu
> Subject: Re: [ RadSafe ] Cl-36 in Nuclear Medicine?
>
>
> 0.01% of the EC involves a B+...
> Being a relatively low energy B+ (ave 50 keV max 120 keV), one can  
> get fine resolution of the origin of the B+ (the B+ won't travel  
> very far before annihilating).
> My guess is that it could be used for some of the small animal PET  
> scanners as a marker source.  Another possibility would be as a test  
> of an imaging systems resolution.
> Imaging technology is getting to the point where the limits on  
> resolution are due to the "fuzziness" of the source and not on the  
> detection technology.  An imaging system might have an intrinsic  
> resolution of 1 mm, but if the B+ travels 2 mm before annihilation  
> then your resolution is limited by that...
>
> Best regards,
> Cary
>
> ---
> Cary Renquist
> cary.renquist at ezag.com
>
>
> -----Original Message-----
> From: radsafe-bounces at health.phys.iit.edu [mailto:radsafe-bounces at health.phys.iit.edu 
> ] On Behalf Of Vernig, Peter G.
> Sent: Friday, 16 July 2010 08:59
> To: ROY HERREN; jearadrat at aol.com; radsafe at health.phys.iit.edu
> Subject: Re: [ RadSafe ] Cl-36 in Nuclear Medicine?
>
> Things have hit around this but I do not believe anybody has stated  
> that Cl-36 is not a positron emitter, it decays primarily by beta  
> emission like 98% and 1% or so electron capture.  So unless  
> something pretty unusual is being done...
>
> Any opinions in this e-mail are solely those of the author, and are  
> not represented as those of the VA Eastern Colorado HCS, the Dept.  
> of Veterans Affairs, or the US Government.
>
> Peter G. Vernig,RSO
>
> -----Original Message-----
> From: radsafe-bounces at health.phys.iit.edu [mailto:radsafe-bounces at health.phys.iit.edu 
> ] On Behalf Of ROY HERREN
> Sent: Friday, July 16, 2010 9:56 AM
> To: jearadrat at aol.com; radsafe at health.phys.iit.edu
> Subject: Re: [ RadSafe ] Cl-36 in Nuclear Medicine?
>
> Another PET isotope that is interesting is Rubidium Rb 82, see
> http://www.cardiogen.com/.  The half life of Rb82 is only 75  
> seconds.  The
> isotope literally goes directly from the generator into an IV and  
> the on into
> the patient who is laying on the PET scanner gantry.
>  Roy Herren
>
>
>
>
> ________________________________
> From: "jearadrat at aol.com" <jearadrat at aol.com>
> To: radsafe at health.phys.iit.edu
> Sent: Thu, July 15, 2010 2:04:34 PM
> Subject: [ RadSafe ] Cl-36 in Nuclear Medicine?
>
>
>
> Good afternoon, all:
>
> In a reqcent company training session, one of my fellow technicians  
> mentioned
> that a nuclear medicine application was being developed for  
> chlorine-36.
> Considering the VERY long (3E5 yrs) half-life, what possible patient  
> application
> can there be for this?  Or is it possible some erroneous information  
> is being
> spread?
>
> Thanks in advance,
> John Aperans, RRPT
> Clinton, TN USA
>
>
> P.S. Please be gentle, this is my first post.
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