[ RadSafe ] MRI as a tool to assess local radiation-induced damage

[Scott, Bobby]

Colleagues:
 
Studies conducted by Pam Syke's group in Australia demonstrated that a low dose of X-rays protected from chromosomal inversions induced by a high dose irrespective of wheter the low dose was given before or after the high dose.
 
Bobby R. Scott
LRRI
E-mail: bscott at LRRI.org

________________________________

From: HOWARD.LONG at comcast.net [mailto:HOWARD.LONG at comcast.net]
Sent: Mon 5/3/2010 9:14 AM
To: Brian G Rees; Scott, Bobby
Cc: Nils Rudqvist; radsafe at health.phys.iit.edu
Subject: Re: [ RadSafe ] MRI as a tool to assess local radiation-induced damage




Not only MRI but also CT (yes, more radiation!) should be considered

to evaluate severe local radiation damage.

Bobby Scott shook us up at a DDP meeting with data suggesting that

low dose radiation reduced damage after rad overdose. Counter intuitive!

Bobby, would you comment?

 

Howard Long

 

----- Original Message -----
From: "Brian G Rees" <brees at lanl.gov>
To: "Nils Rudqvist" <nils.rudqvist at gmail.com>, radsafe at health.phys.iit.edu
Sent: Monday, May 3, 2010 7:52:55 AM GMT -08:00 US/Canada Pacific
Subject: Re: [ RadSafe ] MRI as a tool to assess local radiation-induced damage

IAEA STI/PUB 1106 (THE CRITICALITY ACCIDENT IN SAROV) Discusses the use of CT scans in assessing the victim's condition...

Brian Rees

-----Original Message-----
From: radsafe-bounces at health.phys.iit.edu [mailto:radsafe-bounces at health.phys.iit.edu] On Behalf Of Nils Rudqvist
Sent: Wednesday, April 28, 2010 9:12 AM
To: radsafe at health.phys.iit.edu
Subject: [ RadSafe ] MRI as a tool to assess local radiation-induced damage

Dear radsafers,

I have been reading the TMT Handbook (Triage, Monitoring and Treatment),
http://www.tmthandbook.org/. I found the following text in a chapter
regarding local radiation-induced damage:

"Magnetic resonance imaging (MRI) can be useful in detecting damage in
deeper tissues e.g. muscle. Since MRI may demonstrate oedema and
inflammatory reactions extending well beyond the lesion, these signs cannot
be used alone to guide surgery.",

This can be found on page 291 in the handbook, where they also point to an
article of Peter and Gottlober (2002) as the reference. I have troubles
finding this article and to be honest, i have a hard time finding anything
at all about the clinical use of MRI as an dosimetric instrument. Of course,
one could use MRI to detect lesions and so on, but has it been done? And if
it has been used, to what grade - what absorbed doses could one "detect".

There is some litterature supporting the use of MRI and MRS to look at
higher doses, i.e. lesions in the brain after external radio therapy, but if
one wanted to use MR as a tool to find and do dose-asessments, i dont know
if that is a good idea...

I request your help! If anyone out there have experience of using MR as a
tool for dose-asessment or might know anything at all about it, please
contact me.

Thanks,

Nils Rudqvist
Gothenburg, Sweden
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