[ RadSafe ] LNT

[Busby, Chris]

The problem is this question: what is the ionisation density at the target? This includes non targeted effects, then the ionisation density in the cell or cell community. It is clear from experiments with radiation but also other chemical stressors that the dose response in complex, and usually biphasic. As you say, there are different mechanisms at high dose rate than low dose rate. But the local ionisation density is usually orders of magnitude higher for internal than external irradiation and for second event emitters or sequences or cascades the cell may alter its repair state before a second or third hit. My own belief is that hormesis is an artifact arising from a misunderstanding of the position of the point 0,0.
The current arguments (including the radsafe ones) are very simplistic.
Chris

Esjberg
Denmark 


-----Original Message-----
From: radsafe-bounces at agni.phys.iit.edu on behalf of Otto G. Raabe
Sent: Tue 9/27/2011 12:30 AM
To: The International Radiation Protection (Health Physics) Mailing List
Subject: Re: [ RadSafe ] LNT
 
September 26, 2011

In my HPJ 2011 paper I showed that the LNT model comes from the 
Atomic Bomb Survivor Studies involving instantaneous, high dose-rate 
exposures and it does not apply to protracted or repeated exposures 
which involve a completely different biological processes.

Raabe OG. Toward improved ionizing radiation safety standards. Health 
Phys. 101:84-93; 2011.

I'll send you a copy if your don't have it handy.

Otto


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Prof. Otto G. Raabe, Ph.D., CHP
Center for Health & the Environment
University of California
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