[ RadSafe ] Chemoluminescence in Urine by pharmaceuticals

[Ivor Surveyor]

Urinary chemoluminescence has been known about 
for a long time.  In the early 1960s when I was 
preparing urine specimens for tritium counting, 
the urine specimens were frozen using dry ice and 
subjected to a vacuum distillation process.

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At 06:28 AM 12/01/2012, Mike Quastel wrote:
>Urinary chemoluminescence could interfere with tritium measurements
>if you're dealing with trace levels. See the following examples:
>G. ALAN ROSE  Studies on the Chemical Nature of Urinary
>Chemiluminescence. British Journal of Urology Volume 48, 61­71,1976
><http://onlinelibrary.wiley.com/doi/10.1111/j.1464-410X. 
>1976.tb02744.x/abstract>
>2.      Urinary chemoluminescence is known to be present with renal and
>urinary infection, probably from neutrophils.
> 
><http://www.springerimages.com/Images/MedicineAndPublicHealth/ 
>1-10.1007_s00467-005-1990-x-2>
>
>
>3.      Urinary chemoluminescence is also 
>elevated in smokers. <http:// www.ncbi.nlm.nih.gov/pubmed/7186131>
>
>Gisler GC, Diaz J, Durán N. Electronically excited species in the
>spontaneous chemiluminescence of urine and its uses in the detection
>of pathological conditions.Physiol Chem Phys. 1982;14(4):335-42.
>Regards,Mike
>
>
>
>On Jan 11, 2012, at 8:19 PM, ROMANOWICH Larry(L) - BRUCE POWER wrote:
>
>>Does anyone have a list of pharmaceuticals (none radioactive type)
>>that
>>will cause significant chemoluminescence in an individuals urine
>>sample.
>>We analyse urine samples for tritium via liquid scintillation
>>counting.
>>Concern here is that if the worker is on these pharmaceuticals when
>>submitting bioassay samples, it may impact the tritium result.
>>
>>Larry Romanowich
>>Bruce Power
>>519 389 4046 ext 15556
>>
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Ivor Surveyor
isurveyor at vianet.net.au