[ RadSafe ] Interesting study with a potential radiation mitigating drug

Mon Jan 26 13:45:05 CST 2015

Colette/Radsafe,

      Directly after Chernobyl, there were  responders/workers etc. with 
significant exposures, some lethal I guess.   Dr. Gray and other people tried 
to do bone marrow transplants and possibly other  procedures.  A search on 
chernobyl and gray   or just chernobyl  might help.  Perhaps search gray and 
ucla  also.  Don't know if  he is still there.  I believe he was an MD.  
Books and articles on  chernobyl might help???

      Joe Preisig

In a message dated 1/26/2015 1:56:50 P.M. Eastern Standard Time,  
Colette.Tremblay at ssp.ulaval.ca writes:

What did  Dr. Gray do?

-----Message d'origine-----
De :  radsafe-bounces at health.phys.iit.edu  
[mailto:radsafe-bounces at health.phys.iit.edu] De la part de  JPreisig at aol.com
Envoyé : 23 janvier 2015 19:49
À :  radsafe at health.phys.iit.edu
Objet : Re: [ RadSafe ] Interesting study  with a potential radiation 
mitigating  drug

Colette/Radsafe:

Thanks for the  explanation, Colette.  Sadly,  it reminds me a bit about 
Dr. Gray  (UCLA???) and others trying to save lives  after Chernobyl.

Joe Preisig

In a message dated 1/23/2015 3:45:17 P.M.  Eastern Standard Time, 
Colette.Tremblay at ssp.ulaval.ca writes:

Hi   Joe,

The investigators used a chemical named DBIBB to mitigates in  mice  the 
injuries caused by high-dose ionizing radiation. 

The  substance,  when administered up to 72 hours postirradiation, reduced  
mortality in mice.  DBIBB mitigated the gastrointestinal radiation  
syndrome, reduced programmed  cell death and enhanced DNA repair in the  animals. 
DBIBB also increased the  survival of mice suffering from the  hematopoietic 
acute radiation syndrome  after total-body irradiation.  

The endpoint of the study was mortality  at day 30 following a 15  Gy whole 
body dose. In the control  group, only  one mouse out of 14  per group 
survived to day 30 (93% lethality), and the  mean survival time  was 8 days. In 
a group receiving low dose DBIBB (1 mg/kg,  26 hour after  irradiation), 2 
mice were alive at day 30 and the mean survival  time was  15 days. In the 
high dose group (10 mg/kg), 10 out of 14 mice were alive on  day 30. It opens 
up the possibility of future treatments that could  administered hours, even 
days, after   irradiation.

Colette

-----Message d'origine-----
De :   radsafe-bounces at health.phys.iit.edu   
[mailto:radsafe-bounces at health.phys.iit.edu] De la part de   
JPreisig at aol.com
Envoyé : 22 janvier 2015 16:29
À :   radsafe at health.phys.iit.edu
Objet : Re: [ RadSafe ] Interesting study   with a potential radiation 
mitigating drug

Colette,

What  does all that mean???

Joe  Preisig

In a message  dated 1/22/2015 3:44:42 P.M. Eastern  Standard Time,  
Colette.Tremblay at ssp.ulaval.ca writes:

The   citation is  :

Patil et al., Combined Mitigation of the  Gastrointestinal   and 
Hematopoietic Acute Radiation Syndromes by an LPA2   Receptor-Specific  
Nonlipid 
Agonist, Chemistry & Biology   (2015),
http://dx.doi.org/10.1016/j.chembiol.2014.12.009

The   complete paper is  available free of charge (see link at the end of   
the
citation)

Colette

[cid:image001.gif at 01D0365A.37F58C20]

[cid:image002.gif at 01D0365A.37F58C20]

[cid:image004.gif at 01D0365A.37F58C20]<http://www.ulaval.ca/>

Colette    Tremblay
Spécialiste en radioprotection
Service de sécurité et  de   prévention
Pavillon Ernest-Lemieux, local  1533
Poste    2893

Avis   de
confidentialité<http://www.rec.ulaval.ca/lce/securite/confidentialite.htm>

_______________________________________________
You    are currently subscribed to the RadSafe mailing list

Before  posting  a  message to RadSafe be sure to have read and understood  
the RadSafe  rules.  These can be found at:   
http://health.phys.iit.edu/radsaferules.html

For   information  on how to subscribe or unsubscribe and other  settings
visit:    http://health.phys.iit.edu

_______________________________________________
You   are currently subscribed to the RadSafe mailing list

Before posting  a  message to RadSafe be sure to have read and understood 
the RadSafe  rules.  These can be found at:  
http://health.phys.iit.edu/radsaferules.html

For  information  on how to subscribe or unsubscribe and other settings 
visit:   http://health.phys.iit.edu
_______________________________________________
You   are currently subscribed to the RadSafe mailing list

Before posting  a  message to RadSafe be sure to have read and understood 
the RadSafe  rules.  These can be found at:  
http://health.phys.iit.edu/radsaferules.html

For  information  on how to subscribe or unsubscribe and other settings 
visit:   http://health.phys.iit.edu
_______________________________________________
You  are currently subscribed to the RadSafe mailing list

Before posting a  message to RadSafe be sure to have read and understood 
the RadSafe rules.  These can be found at: 
http://health.phys.iit.edu/radsaferules.html

For  information on how to subscribe or unsubscribe and other settings 
visit:  http://health.phys.iit.edu
_______________________________________________
You  are currently subscribed to the RadSafe mailing list

Before posting a  message to RadSafe be sure to have read and understood 
the RadSafe rules.  These can be found at: 
http://health.phys.iit.edu/radsaferules.html

For  information on how to subscribe or unsubscribe and other settings 
visit:  http://health.phys.iit.edu