[ RadSafe ] Interesting study with a potential radiation mitigating drug

[JPreisig at aol.com]

Colette/Radsafe,
 
     The Doctor was Dr. Gale.....A search on chernobyl  and bone marrow 
gives some good results.
 
     Joe Preisig
 
 
 
 
In a message dated 1/26/2015 1:56:50 P.M. Eastern Standard Time,  
Colette.Tremblay at ssp.ulaval.ca writes:

What did  Dr. Gray do?

-----Message d'origine-----
De :  radsafe-bounces at health.phys.iit.edu  
[mailto:radsafe-bounces at health.phys.iit.edu] De la part de  JPreisig at aol.com
Envoyé : 23 janvier 2015 19:49
À :  radsafe at health.phys.iit.edu
Objet : Re: [ RadSafe ] Interesting study  with a potential radiation 
mitigating  drug

Colette/Radsafe:

Thanks for the  explanation, Colette.  Sadly,  it reminds me a bit about 
Dr. Gray  (UCLA???) and others trying to save lives  after Chernobyl.

Joe Preisig


In a message dated 1/23/2015 3:45:17 P.M.  Eastern Standard Time, 
Colette.Tremblay at ssp.ulaval.ca writes:

Hi   Joe,

The investigators used a chemical named DBIBB to mitigates in  mice  the 
injuries caused by high-dose ionizing radiation. 

The  substance,  when administered up to 72 hours postirradiation, reduced  
mortality in mice.  DBIBB mitigated the gastrointestinal radiation  
syndrome, reduced programmed  cell death and enhanced DNA repair in the  animals. 
DBIBB also increased the  survival of mice suffering from the  hematopoietic 
acute radiation syndrome  after total-body irradiation.  

The endpoint of the study was mortality  at day 30 following a 15  Gy whole 
body dose. In the control  group, only  one mouse out of 14  per group 
survived to day 30 (93% lethality), and the  mean survival time  was 8 days. In 
a group receiving low dose DBIBB (1 mg/kg,  26 hour after  irradiation), 2 
mice were alive at day 30 and the mean survival  time was  15 days. In the 
high dose group (10 mg/kg), 10 out of 14 mice were alive on  day 30. It opens 
up the possibility of future treatments that could  administered hours, even 
days, after   irradiation.

Colette

-----Message d'origine-----
De :   radsafe-bounces at health.phys.iit.edu   
[mailto:radsafe-bounces at health.phys.iit.edu] De la part de   
JPreisig at aol.com
Envoyé : 22 janvier 2015 16:29
À :   radsafe at health.phys.iit.edu
Objet : Re: [ RadSafe ] Interesting study   with a potential radiation 
mitigating drug

Colette,

What  does all that mean???

Joe  Preisig




In a message  dated 1/22/2015 3:44:42 P.M. Eastern  Standard Time,  
Colette.Tremblay at ssp.ulaval.ca writes:

The   citation is  :

Patil et al., Combined Mitigation of the  Gastrointestinal   and 
Hematopoietic Acute Radiation Syndromes by an LPA2   Receptor-Specific  
Nonlipid 
Agonist, Chemistry & Biology   (2015),
http://dx.doi.org/10.1016/j.chembiol.2014.12.009

The   complete paper is  available free of charge (see link at the end of   
the
citation)

Colette

[cid:image001.gif at 01D0365A.37F58C20]

[cid:image002.gif at 01D0365A.37F58C20]

[cid:image004.gif at 01D0365A.37F58C20]<http://www.ulaval.ca/>




Colette    Tremblay
Spécialiste en radioprotection
Service de sécurité et  de   prévention
Pavillon Ernest-Lemieux, local  1533
Poste    2893

Avis   de
confidentialité<http://www.rec.ulaval.ca/lce/securite/confidentialite.htm>


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