RE: Toxic Trivia - Nicotine

["Boyce, Dale" <DBoyce@intiso.com>]

from the Merck
nicotine LD50 in mice mg/kg  0.3 i.v. 9.5 i.p. 230 oral

I'll have to try to come up with a reference at home, but the toxins from
botulinus and tetnus are both far more toxic. Somewhere in the fraction of a
nanogram/kilogram range if I remember correctly. I believe that I remember
that they catalytically break H-S bonds so that each molecule can just keep
on killing.

> -----Original Message-----
> From:	Glenn Roberts [SMTP:glenn@u1st.com]
> Sent:	Thursday, February 10, 2000 1:13 PM
> To:	Multiple recipients of list
> Subject:	Toxic Trivia - Nicotine
> 
> I am at a loss right now no longer having direct responsibility for
> chemical safety and haz waste in a laboratory setting.  However, I
> recall pure chemical nicotine being one of the most toxic substance by
> weight.
> 
> Can anyone confirm.
> 
> Glenn Roberts
> 
> 
> 
> "Otto G. Raabe" wrote:
> > 
> > At 10:09 AM 02/10/2000 -0600, Ron Amoling wrote:
> > >I was at a hazardous materials course yesterday and the instructor
> listed
> > >Sr-90 as one of the most toxic substances on earth.  Any opinions?
> > >
> > ************************
> > Is this on a weight basis for ingestion? Then other radiative materials
> are
> > more toxic. Is this for short-term effects or delayed effects like
> cancer?
> > For short-term effects more toxic substances include:
> > 
> > (1) Amanita muscaris, the "death angel" mushroom
> > (2) Botulinum toxin
> > (3) dimethyl mercury
> > (4) fluorine gas
> > (5) VX or VG
> > 
> > Otto
> > 
> >                 *****************************************************
> >                 Prof. Otto G. Raabe, Ph.D., CHP
> >               Institute of Toxicology & Environmental Health (ITEH)
> >                    (Street address: Building 3792, Old Davis Road)
> >                 University of California, Davis, CA 95616
> >                 Phone: 530-752-7754  FAX: 530-758-6140
> >                 E-mail ograabe@ucdavis.edu
> >               *****************************************************
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