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RE: Thank you for your encouragement Re: discussion of "effectivedose"
Hi John,
In addition to Harald's letter in the Mar '96 HPJ, you may want to see
his review paper in the Jun '96 HPJ, [70(6):828-31] "Radiation
physics and radiobiology."
Kellerer has a paper in the same issue: "Radiobiological challenges
posed by microdosimetry."
and there's: Chen J, Kellerer AM, Rossi HH. "On the revised concept
of linear energy transfer." Radiat Environ Biophys. 1995
Mar;34(1):29-35.
Of possible interest:
Hawkins RB. "A microdosimetric-kinetic model of cell death from
exposure to ionizing radiation of any LET, with experimental and
clinical applications." Int J Radiat Biol. 1996 Jun;69(6):739-55.
There's lot at high doses (therapy, cell killing), with the following at
low dose:
Radiat Meas 2001 Jun;34(1-6):105-8
About some physical mechanisms of statistics of radiation-induced
effects formation and non-linear cell response in low dose area.
Rusov V, Zelentsova T, Melentchuk I, Beglaryan M.
Department of Theoretical and Experimental Nuclear Physics, Odessa
Polytechnic University, Shevchenko av I, Odessa 65044, Ukraine.
siiis@e.net.ua
A new cascade-stochastic approach to solve the direct and inverse
problems of radiation-induced effect statistics in track biodetectors is
presented in this paper. The analysis of the experimental data has made
it possible to establish a non-linear nature of the "dose-effect"
dependence in low dose area. For the first time, a new determination of
the relative biological efficiency and quality coefficient of ionizing
radiation in area of low doses are proposed. c2000 Published by Elsevier
Science Ltd.
[At least it's an Elsevier pub :-)]
Regards, Jim
-----Original Message-----
From: John Cameron
Sent: Mon 14-Jan-02 11:12 AM
To: Christoph Hofmeyr
Cc: radsafe@list.vanderbilt.edu
Subject: Thank you for your encouragement Re: discussion of
"effectivedose"
Dear Chris
I hope others feel it would be useful. A problem is that few health
physicists have thought about this problem. There are two books
which would provide relevant background (besides NCRP Report No. 104
on RBE):
Radiation Protection Quantities: A Radical Reappraisal by Jack
Simmons and David Watt
available for Medical Physics Publishing (www.medicalphysics.org)
and Has Radiation Protection become a health hazard Gunnar Walinder
co-published by Medical Physics Publishing.
The following articles by Harald Rossi discuss some aspects
of the problem:
Rossi, H.H. Limitation and assessment in radiation protection. 8th
Lauriston Taylor Lecture. National Council on Radiation Protection
and Measurement. Bethesda, MD; 1984.
Rossi, H.H. Sensible radiation protection. Health Physics.70(3): 394;
1996.
[In this article Rossi states that radiation protection quantities
are in a "state of chaos."]
Rossi, H.H. Zaider, M. Radiogenic lung cancer. The effects of low
doses of low-LET radiation. Rad. and Env. Biophys. 36(2): 85; 1997.
Rossi, H.H. It is Time for Change HPS Newsletter December 1997 pp 8-9
Rossi, H.H. LN-T and Politics HPS Newsletter January 2000
I am sure there must be other relevant articles but I'm not
aware of them. In 1995 I tried to publish a critique of radiation
protection quantities in Health Physics but it was rejected as "an
attack on NCRP". Of course, that is part of the problem.
Your suggestions would be welcome. It will take many years
before any changes can be made. Discussing it on the list server
should help the education part of the problem.
Best wishes, John
--
John R. Cameron, Ph.D.
Professor Emeritus,UW-Madison
Departments of Medical Physics, Radiology & Physics
Winter home address:
2678 SW 14th Dr.
Gainesville, FL 32608
(352) 371-9865 FAX 371-9866
e-mail: jrcamero@facstaff.wisc.edu