Re: FW: bad news about coffee

[Norman Cohen <ncohen12@HOME.COM>]

John,

Doesn't this mean that hormesis does not work with coffee? Maybe we need LLT

(Liquid, Large Threshold) for coffee.  ;-)

norm



"Jacobus, John (OD/ORS)" wrote:



> I received this on another list server.  I guess I will need to increase the

> dosage beyond my normal daily dose of 10 cups a day.

>

> -- John

> John Jacobus, MS

> Certified Health Physicist

> 3050 Traymore Lane

> Bowie, MD  20715-2024

>

> E-mail:  jenday1@email.msn.com (H)

>

> -----Original Message-----

> . . .

>

> For my fellow caffeine addicts, there is an interesting paper in this

> month's Radiation Research (Caffeine induces TP53-independent G1 phase

> arrest and apoptosis in human lung tumor cells in a dose-dependent manner,

> Qi et al., Radiation Research 157:166-174).  It looks as though low doses of

> caffeine help to block G2 phase arrest that is normally seen after exposure

> to radiation and can let a damaged cell go forward in the cell cycle.  On

> the other hand, large doses of caffeine helps induce apoptosis by itself and

> acts to synergistically enhance radiation-induced apoptosis and G1 phase

> arrest.  This happens at levels about 10 times as high as the "bad" effects.

> So I guess that the moral of the story is that, if you're going to drink

> coffee, it's best to drink a LOT.  The paper didn't tell how many cups of

> coffee you have to drink to get to either of these effects.

>

> Andy

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