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RE: First neutron therapy procedure on the explanted human liver [FW]
Jaro,
Is it just me, but this seems like a bizarre treatment plan.
1. Inject patient with boron-labeled compound
2. Remove liver
3. Irradiate liver
4. Implant liver back into patient.
I also question the evaluation of success based on CT images to visualize
the "metastases in a necrosis condition while the normal tissues appear well
preserved." Of course, long term survival of the patient may not be the
outcome they were evaluating.
-- John
John Jacobus, MS
Certified Health Physicist
3050 Traymore Lane
Bowie, MD 20715-2024
E-mail: jenday1@email.msn.com (H)
-----Original Message-----
From: Franta, Jaroslav [mailto:frantaj@AECL.CA]
Sent: Monday, February 18, 2002 9:40 AM
To: multiple (E-mail); Radsafe (E-mail)
Subject: First neutron therapy procedure on the explanted human liver [FW]
Good news from the BNCT research community....
Jaro
-----Original Message-----
From: Wolfgang Sauerwein [mailto:w.sauerwein@UNI-ESSEN.DE]
Sent: Sunday February 17, 2002 1:40 PM
To: BNCT@MITVMA.MIT.EDU
Subject: Fwd: First procedure on the explanted human liver
. . .
At 8 a.m. of Wednesday December 19 (2001) the surgical team directed by
Prof. A. Zonta started, at San Matteo Polyclinic of Pavia, the procedure of
liver self-transplant in a man 48 years old. Starting from 3.15 p.m. a
BPA-Fructose solution (BPA dose of 300 mg per Kg. of the patient body) was
intravenously administered for 2 hrs.
After 1 and 2 hrs, biopsies of tumor and normal hepatic tissues were
performed for the boron concentration measurement. The liver after having
been explanted at 7.50 p.m. has been transferred to the Applied Nuclear
Energy Laboratory (LENA) of the University of Pavia at 8.30 p.m.
Having previously measured the boron concentration in both cancerous and
normal tissues, and defined the treatment plan, the Physicist team, directed
by Prof. T. Pinelli, submitted the liver to a neutron irradiation up to
reach a fluence of 4x1012 cm-2 (around 11 m.) at the irradiation position
inside the thermal column of the Triga Mark II reactor. At 9.15 p.m. the
treated liver returned to the surgery room and reimplanted starting from
9.55 p.m.
The procedure was completed at 6.15 a.m. of December 20.
The patient was recovered at the reanimation department for about 2 weeks
and discharged Friday January 25 (2002).
Before leaving the San Matteo Polyclinic the patient recovered all his
normal function and appeared in good general conditions.
As regarding the result of the therapy the Computer Assisted Tomography
shows all metastases in a necrosis condition while the normal tissues appear
well preserved.
It's important to remark that, due to the sharp imagine of the necrotic
tissues, the number of the treated metastases appear larger with respect to
those evidenced, before the neutron therapy, by the various diagnostic tools
(about 20 Vs 14).
The entire operation has been attended by all researchers participating to
the 13 years TAOrMINA project (see attached cover)
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