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Re: First neutron therapy procedure on the explanted human liver [FW]
Good point John, better to just let them die. That might be OK for people
like my mother, who died at age 85 after almost pointless major cancer
surgery (nothing bizarre about that) or like my father-in-law who died at
age 75 after almost pointless brain surgery and radiation treatments
(nothing bizarre about that either). But perhaps younger people deserve a
chance to live a little longer.
Don Kosloff dkosloff1@msn.com
2910 Main Street
----- Original Message -----
From: "Jacobus, John (OD/ORS)" <jacobusj@ors.od.nih.gov>
To: "Franta, Jaroslav" <frantaj@AECL.CA>; "multiple (E-mail)"
<cdn-nucl-l@informer2.cis.McMaster.CA>; "Radsafe (E-mail)"
<radsafe@list.vanderbilt.edu>
Sent: Friday, February 22, 2002 8:21 AM
Subject: RE: First neutron therapy procedure on the explanted human liver
[FW]
> Jaro,
> Is it just me, but this seems like a bizarre treatment plan.
> 1. Inject patient with boron-labeled compound
> 2. Remove liver
> 3. Irradiate liver
> 4. Implant liver back into patient.
>
> I also question the evaluation of success based on CT images to visualize
> the "metastases in a necrosis condition while the normal tissues appear
well
> preserved." Of course, long term survival of the patient may not be the
> outcome they were evaluating.
>
> -- John
> John Jacobus, MS
> Certified Health Physicist
> 3050 Traymore Lane
> Bowie, MD 20715-2024
>
> E-mail: jenday1@email.msn.com (H)
>
> -----Original Message-----
> From: Franta, Jaroslav [mailto:frantaj@AECL.CA]
> Sent: Monday, February 18, 2002 9:40 AM
> To: multiple (E-mail); Radsafe (E-mail)
> Subject: First neutron therapy procedure on the explanted human liver [FW]
>
> Good news from the BNCT research community....
> Jaro
> -----Original Message-----
> From: Wolfgang Sauerwein [mailto:w.sauerwein@UNI-ESSEN.DE]
> Sent: Sunday February 17, 2002 1:40 PM
> To: BNCT@MITVMA.MIT.EDU
> Subject: Fwd: First procedure on the explanted human liver
>
> . . .
>
> At 8 a.m. of Wednesday December 19 (2001) the surgical team directed by
> Prof. A. Zonta started, at San Matteo Polyclinic of Pavia, the procedure
of
> liver self-transplant in a man 48 years old. Starting from 3.15 p.m. a
> BPA-Fructose solution (BPA dose of 300 mg per Kg. of the patient body) was
> intravenously administered for 2 hrs.
>
> After 1 and 2 hrs, biopsies of tumor and normal hepatic tissues were
> performed for the boron concentration measurement. The liver after having
> been explanted at 7.50 p.m. has been transferred to the Applied Nuclear
> Energy Laboratory (LENA) of the University of Pavia at 8.30 p.m.
>
> Having previously measured the boron concentration in both cancerous and
> normal tissues, and defined the treatment plan, the Physicist team,
directed
> by Prof. T. Pinelli, submitted the liver to a neutron irradiation up to
> reach a fluence of 4x1012 cm-2 (around 11 m.) at the irradiation position
> inside the thermal column of the Triga Mark II reactor. At 9.15 p.m. the
> treated liver returned to the surgery room and reimplanted starting from
> 9.55 p.m.
>
> The procedure was completed at 6.15 a.m. of December 20.
>
> The patient was recovered at the reanimation department for about 2 weeks
> and discharged Friday January 25 (2002).
>
> Before leaving the San Matteo Polyclinic the patient recovered all his
> normal function and appeared in good general conditions.
>
> As regarding the result of the therapy the Computer Assisted Tomography
> shows all metastases in a necrosis condition while the normal tissues
appear
> well preserved.
>
> It's important to remark that, due to the sharp imagine of the necrotic
> tissues, the number of the treated metastases appear larger with respect
to
> those evidenced, before the neutron therapy, by the various diagnostic
tools
> (about 20 Vs 14).
>
> The entire operation has been attended by all researchers participating to
> the 13 years TAOrMINA project (see attached cover)
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