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UV-B ecologic studies
Two recent ecologic studies by Bill Grant bgrant@infi.net
Dr. Cohen has recently stated he would be glad to
explain how any other ecologic studies could produce an
erroneous inverse assocation. Dr. Cohen would you be
willing to show how these studies could produce the
inverse associations they found?
If not, pehaps this is a "treatment" worth adding to
your ecologic studies? Bill could likely send you his
ecologic data files for sun exposure.
Regards, Bill
Cancer 2002 Mar 15;94(6):1867-75
An estimate of premature cancer mortality in the U.S.
due to inadequate doses of solar ultraviolet-B radiation.
Grant WB.
BACKGROUND: There are large geographic gradients in
mortality rates for a number of cancers in the U.S.
(e.g., rates are approximately twice as high in the
northeast compared with the southwest). Risk factors
such as diet fail to explain this variation. Previous
studies have demonstrated that the geographic
distributions for five types of cancer are related
inversely to solar radiation. The purpose of the current
study was to determine how many types of cancer are
affected by solar radiation and how many premature
deaths from cancer occur due to insufficient ultraviolet
(UV)-B radiation. METHODS: UV-B data for July 1992 and
cancer mortality rates in the U.S. for between 1970-1994
were analyzed in an ecologic study. RESULTS: The
findings of the current study confirm previous results
that solar UV-B radiation is associated with reduced
risk of cancer of the breast, colon, ovary, and prostate
as well as non-Hodgkin lymphoma. Eight additional
malignancies were found to exhibit an inverse
correlation between mortality rates and UV-B radiation:
bladder, esophageal, kidney, lung, pancreatic, rectal,
stomach, and corpus uteri. The annual number of
premature deaths from cancer due to lower UV-B exposures
was 21,700 (95% confidence interval [95% CI], 20,400-
23,400) for white Americans, 1400 (95% CI, 1100-1600)
for black Americans, and 500 (95% CI, 400-600) for Asian
Americans and other minorities. CONCLUSIONS: The results
of the current study demonstrate that much of the
geographic variation in cancer mortality rates in the
U.S. can be attributed to variations in solar UV-B
radiation exposure. Thus, many lives could be extended
through increased careful exposure to solar UV-B
radiation and more safely, vitamin D3 supplementation,
especially in nonsummer months. Copyright 2002 American
Cancer Society.
Cancer 2002 Jan 1;94(1):272-81
An ecologic study of dietary and solar ultraviolet-B
links to breast carcinoma mortality rates.
Grant WB.
Newport News, Virginia, USA.
BACKGROUND: The role of diet in the etiology of breast
carcinoma has been debated for decades. The ecologic
approach generally finds that dietary fat is highly
associated with breast carcinoma mortality, with fish
intake and solar ultraviolet-B (UV-B) radiation, a
source of vitamin D, inversely associated. Case-control
and cohort studies generally find a variety of chemical,
nonfat dietary, environmental, genetic, lifestyle, and
reproductive factors to be important. METHODS: An
ecologic study was conducted using breast carcinoma
mortality rates (1989-1996), dietary supply data, and
latitude (an index of solar UV-B radiation) from 35
countries. RESULTS: The fraction of energy derived from
animal products (risk) combined with that from vegetable
products (risk reduction), followed by solar UV-B
radiation and, to a lesser extent, energy derived from
alcohol (risk) and fish intake (risk reduction), were
found to explain 80% of the variance of breast carcinoma
mortality rates. Dietary fat contributed insignificantly
in regressions involving the other factors. CONCLUSIONS:
It is hypothesized that animal products are associated
with risk for breast carcinoma because they are
associated with greater amounts of insulin-like growth
factor-1 and lifetime doses of estrogen. Vegetable
products contain several risk reduction components
including antioxidants and phytoestrogens. The
association with latitude is very likely because of
solar UV-B radiation and vitamin D. Alcohol modulates
estrogen's effects on breasts. Fish intake is associated
with risk reduction through vitamin D and n-3 oils.
These results are consistent with those of many case-
control and cohort studies but should be assessed in
well designed cohort studies. Copyright 2002 American
Cancer Society.
> From: "Jacobus, John (OD/ORS)" <jacobusj@ors.od.nih.gov>
>
> > Jim,
> > Actually, they did address a number of the studies that you cited to the
> > NCRP. In fact, you are listed twice in the list of references. The issue
>
> John, What crap! Grow up.
> You know nothing (or do you?) but defend dishonesty. You reject the
> report's own statements. I reported our 5 years of up-close SC1-6 / NRC
> experience. You can get/read NRC transcripts and letters. At their HPS 136
> report release we got strong applause by those who actually know what's
> going on! Meinhold and Upton were, as always, dismal and unable to respond.
> (They ALSO lamely said: "We referred to your document." That was in the '98
> draft! But when pushed, they told NRC in Mar '99 they'd do more than make a
> ref, they'd review the data. They didn't. It's plain in the text.
> -Jim (Can't imagine this gets any better)
>
>
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