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Re: UV-B ecologic studies
On Sun, 28 Apr 2002 epirad@mchsi.com wrote:
> Two recent ecologic studies by Bill Grant bgrant@infi.net
>
> Dr. Cohen has recently stated he would be glad to
> explain how any other ecologic studies could produce an
> erroneous inverse assocation. Dr. Cohen would you be
> willing to show how these studies could produce the
> inverse associations they found?
--The abstracts do not give enough info for me to make a
judgement. If I could get copies of the papers, I would be glad to look
further. Our medical library is not close by. How would I present the
results of my efforts?
>
> If not, pehaps this is a "treatment" worth adding to
> your ecologic studies? Bill could likely send you his
> ecologic data files for sun exposure.
>
> Regards, Bill
>
>
> Cancer 2002 Mar 15;94(6):1867-75
>
>
> An estimate of premature cancer mortality in the U.S.
> due to inadequate doses of solar ultraviolet-B radiation.
>
> Grant WB.
>
> BACKGROUND: There are large geographic gradients in
> mortality rates for a number of cancers in the U.S.
> (e.g., rates are approximately twice as high in the
> northeast compared with the southwest). Risk factors
> such as diet fail to explain this variation. Previous
> studies have demonstrated that the geographic
> distributions for five types of cancer are related
> inversely to solar radiation. The purpose of the current
> study was to determine how many types of cancer are
> affected by solar radiation and how many premature
> deaths from cancer occur due to insufficient ultraviolet
> (UV)-B radiation. METHODS: UV-B data for July 1992 and
> cancer mortality rates in the U.S. for between 1970-1994
> were analyzed in an ecologic study. RESULTS: The
> findings of the current study confirm previous results
> that solar UV-B radiation is associated with reduced
> risk of cancer of the breast, colon, ovary, and prostate
> as well as non-Hodgkin lymphoma. Eight additional
> malignancies were found to exhibit an inverse
> correlation between mortality rates and UV-B radiation:
> bladder, esophageal, kidney, lung, pancreatic, rectal,
> stomach, and corpus uteri. The annual number of
> premature deaths from cancer due to lower UV-B exposures
> was 21,700 (95% confidence interval [95% CI], 20,400-
> 23,400) for white Americans, 1400 (95% CI, 1100-1600)
> for black Americans, and 500 (95% CI, 400-600) for Asian
> Americans and other minorities. CONCLUSIONS: The results
> of the current study demonstrate that much of the
> geographic variation in cancer mortality rates in the
> U.S. can be attributed to variations in solar UV-B
> radiation exposure. Thus, many lives could be extended
> through increased careful exposure to solar UV-B
> radiation and more safely, vitamin D3 supplementation,
> especially in nonsummer months. Copyright 2002 American
> Cancer Society.
>
> Cancer 2002 Jan 1;94(1):272-81
>
>
> An ecologic study of dietary and solar ultraviolet-B
> links to breast carcinoma mortality rates.
>
> Grant WB.
>
> Newport News, Virginia, USA.
> BACKGROUND: The role of diet in the etiology of breast
> carcinoma has been debated for decades. The ecologic
> approach generally finds that dietary fat is highly
> associated with breast carcinoma mortality, with fish
> intake and solar ultraviolet-B (UV-B) radiation, a
> source of vitamin D, inversely associated. Case-control
> and cohort studies generally find a variety of chemical,
> nonfat dietary, environmental, genetic, lifestyle, and
> reproductive factors to be important. METHODS: An
> ecologic study was conducted using breast carcinoma
> mortality rates (1989-1996), dietary supply data, and
> latitude (an index of solar UV-B radiation) from 35
> countries. RESULTS: The fraction of energy derived from
> animal products (risk) combined with that from vegetable
> products (risk reduction), followed by solar UV-B
> radiation and, to a lesser extent, energy derived from
> alcohol (risk) and fish intake (risk reduction), were
> found to explain 80% of the variance of breast carcinoma
> mortality rates. Dietary fat contributed insignificantly
> in regressions involving the other factors. CONCLUSIONS:
> It is hypothesized that animal products are associated
> with risk for breast carcinoma because they are
> associated with greater amounts of insulin-like growth
> factor-1 and lifetime doses of estrogen. Vegetable
> products contain several risk reduction components
> including antioxidants and phytoestrogens. The
> association with latitude is very likely because of
> solar UV-B radiation and vitamin D. Alcohol modulates
> estrogen's effects on breasts. Fish intake is associated
> with risk reduction through vitamin D and n-3 oils.
> These results are consistent with those of many case-
> control and cohort studies but should be assessed in
> well designed cohort studies. Copyright 2002 American
> Cancer Society.
>
> > From: "Jacobus, John (OD/ORS)" <jacobusj@ors.od.nih.gov>
> >
> > > Jim,
> > > Actually, they did address a number of the studies that you cited to the
> > > NCRP. In fact, you are listed twice in the list of references. The issue
> >
> > John, What crap! Grow up.
> > You know nothing (or do you?) but defend dishonesty. You reject the
> > report's own statements. I reported our 5 years of up-close SC1-6 / NRC
> > experience. You can get/read NRC transcripts and letters. At their HPS 136
> > report release we got strong applause by those who actually know what's
> > going on! Meinhold and Upton were, as always, dismal and unable to respond.
> > (They ALSO lamely said: "We referred to your document." That was in the '98
> > draft! But when pushed, they told NRC in Mar '99 they'd do more than make a
> > ref, they'd review the data. They didn't. It's plain in the text.
> > -Jim (Can't imagine this gets any better)
> >
> >
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