Effects of Tolerable Stress levels

["Ted Rockwell" <tedrock@CPCUG.ORG>]

FYI





Longevity and aging: beneficial effects of exposure to mild stress.



Minois N.

University of Minnesota, Department of Ecology, Evolution, and Behavior, 100

Ecology Building, 1987 Upper Buford Circle, St Paul, MN 55108, USA.

minoi002@tc.umn.edu



Biogerontology 2000;1(1):15-29



Every organism has to deal with exposure to stresses. Animals have developed

various strategies to cope with stress. It appears that the developed

resistance to stress is often related to longevity. Some scientists have

advanced the hypothesis that the stress response may also counteract the

negative effects of aging, and that exposing organisms to a mild, sublethal

stress, inducing a stress response, may help them to live longer. Several

mild stresses have been reported to increase longevity (irradiation, heat

and cold shock, hypergravity, exercise, etc.), and one of them,

hypergravity, to decrease the rate of behavioral aging. The mechanisms

whereby these stresses increase longevity have not yet been elucidated.

However, the studies conducted so far show that they may involve metabolic

regulation and stress protein (hsps) induction.



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