Another request for paper/comments

[Muckerheide <muckerheide@attbi.com>]

> Group,

> 

> Can you provide the following paper?

> Do you have comments?

> 

> Regards, Jim

> ====================

> 

> Oncol Res 2002;13(1):9-18

> 

> Dose and timing of total-body irradiation mediate tumor progression and

> immunomodulation.

> 

> Miller GM, Kajioka EH, Andres ML, Gridley DS.

> Department of Microbiology & Molecular Genetics, Loma Linda University and

> Medical Center, CA 92354, USA.

> 

> The major goal of this study was to examine the effects of total-body

> irradiation (TBI) on lung carcinoma progression and determine if changes in

> tumor growth could be correlated with radiation-induced alterations of immune

> system parameters. Lewis lung tumor cells were injected subcutaneously into

> syngeneic C57BL/6 mice that had been irradiated with a single 3.0 Gy dose of

> gamma-rays (60Co) at four time points either before or after tumor cell

> implantation. Subsequently, a second group of mice was irradiated 2 h prior to

> tumor injection with sequential doses of gamma-rays (0.46-2.66 Gy range).

> Assays were performed on blood and spleen from mice euthanized 16 days

> postimplantation. Tumor growth was consistently slower regardless of the

> timing of radiation exposure. However, dose of radiation influenced tumor

> growth delay. The preirradiated tumor-bearing mice had high CD4/CD8 T

> lymphocyte ratios along with increasing percentages of NKT cells in the blood

> supply with dose. Tumor-induced immunomodulation was also present, as

> evidenced by splenomegaly, low proliferative response to mitogens, and

> decreased spontaneous blastogenesis of leukocytes within the blood compared

> with normal values (P < or = 0.01). Anemia and thrombocytopenia were not

> observed with either tumor presence or irradiation. The present study

> demonstrates that a modest dose of TBI prior to tumor cell implantation

> resulted in a beneficial antitumor effect. A selective radiation-induced

> depletion of CD8+ T lymphocytes and changes in NKT cell percentages,

> correlated with findings from cytotoxicity assays, were indicative of a

> protumoricidal immune environment.



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