Re: Dr.Gofman--I just wonder..

["Cary Renquist" <crenquis@med.umich.edu>]

>>> Steven Dapra <sjd@swcp.com> 06/04/2003 22:27:53 >>>

June 4, 2003



>	This thread began on May 31 when NiagaraNet (NN) made a posting

about John

>Gofman.  Approximately 85% of NN's posting was about Gofman - his

longevity

>in speaking and writing about radioactivity and a brief biography of

>Gofman's early years.  NN also made the claim that Gofman had linked

>radiation exposure to heart disease.



>	Despite more than one request, NN has been unable to give a

citation to

>Gofman's work proving or substantiating a link between rad exposure

and

>heart disease.  Today NN says, "HOWEVER, I don't need the actual

citation"

>(NN's upper case) because he has "three (3) separate and diverse news

>sources," including "a US Senator, a hospital president, a Mayo

trained

>cardiologist and the owner of GEICO Insurance."  (I count four, but NN

said

>three.)



I remember coming across many papers on radiation induced coronary

artery disease, CAD, 

when I was researching radiation therapy for CAD many years ago...



Mind you, the effect was associated with high dose rate radiation.

A quick medline search "radiation coronary stenosis"  should  yield

several papers (limit the search

to before 1998 or you will have to wade through a plethora of

"radiation therapy for restenosis" papers).



Here are two abstracts:

Clin Cardiol 1992 Jun;15(6):459-61    (ISSN: 0160-9289) Chinnasami BR;

Schwartz RC; Pink SB; Skotnicki RA 

Department of Medicine, Polyclinic Medical Center, Harrisburg,

Pennsylvania 17110. This report draws an 

association between mediastinal irradiation and isolated left main

coronary artery stenosis. The report highlights 

two patients who developed selective left main coronary artery stenosis

post mediastinal treatment. In the animal 

model, it has been shown that high serum cholesterol levels at the time

of, or soon after, irradiation are necessary to 

initiate arteriosclerotic plaque formation.



Am J Cardiol 1996 Jul 1;78(1):114-5    (ISSN: 0002-9149) Mittal S;

Berko B; Bavaria J; Herrmann HC Cardiovascular 

Divisions, Princeton Medical Center, New Jersey, USA. Coronary artery

disease and valvular dysfunction are long-term 

complications of mediastinal irradiation. We describe 3 patients who

underwent successful combined coronary artery 

bypass grafting and valve replacement for symptoms related to

radiation-induced coronary artery and valvular disease.



Cary



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