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Re: Mossman paper in Health Physics News - The Debate is Over
Dr. Cohen,
I know you will disagree with this statement, but in my opinion, you have not
responded to many of my points in either a direct or convincing fashion. In
fact, in many cases, you have ignored my points focusing rather on what you
thought you could respond to.
I will pick one instance where we in a publication in the HPJ suggested a
plausible reason for your inverse findings. In Field, R.W., Smith, B.J. and
Lynch, C.F. Ecologic Bias Revisited, A Rejoinder to Cohen’s Response to
Residential radon-222 exposure and lung cancer: testing the linear no-threshold
theory with ecologic data. Health Physics. 75(1): 31-33, 1998. We
stated, “Cohen’s inability to eliminate the residual confounding of smoking
provides a plausible reason for his observed negative correlation between mean
county radon concentrations and lung cancer mortality.”
In the previous email I pointed out that - your smoking data is co-correlated
with socioeconomic status, poor health care, apartment living, mobility, lower
education status, etc. You have never assessed all these variables in a
multivariate analyses. And in fact, this would be impossible to adequately
because of the non linear relationships between these factors within and
between counties.
Your often repeated response is “Even a perfect negative S-r correlation does
not give a positive b value”.
My response has been over the years is that you can not just look at your
estimated county smoking information, you must also look at the co-variates of
county smoking. Additional use of poor summary county smoking data alone can
not be used to validate your findings.
I respectfully understand that you will not agree that residual confounding
from smoking, and co-correlated variables, is a plausible explanation so
according to your latest offer stating that you “would be happy to accept the
judgment of a prominent scientist (with no prior opinions about my study)
mutually agreed to by the submitter and myself, and willing to publish a paper
on this with the submitter and myself as coauthors, with each of us explaining
our viewpoints", please suggest a few scientists whose decision you would
accept.
I am sure we would also both welcome suggestions on scientists from Radsafe.
Honestly though, I am not sure how one can really validate that the scientist
has no a priori opinion on this matter.
Please understand I do not want any award, but rather a conclussion to this
debate.
I do agree with Mossman that it is up to Dr. Cohen to offer real evidence that
radon has a protective effect under about 300 Bq/m3. The residential case-
control studies do not support the presumption that radon has a protective
effect. And as we know, findings from ecologic studies are "validated" using
analytic studies such as case-control studies (not the other way around).
Bill Field
epirad@mchsi.com
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