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RE: Synergistic Interaction in the Carcinogenesis due to radon and smoking
Hi all,
Sometimes it is better to do a literature search before
sounding off! Well, sometimes the literature coverage of
the search engines is a bit late in starting with their
coverage. So, let us leave it at that.
Be that as it may, there are two papers in the literature
that are not so ancient and that do consider a 'multiplicative'
synergism in the interaction of radon and smoking in lung
carcinogenesis:
The original work is by:
Whittemore, A.S., and A. McMillan. "Lung Cancer Mortality
among U.S. Uranium Miners: A reappraisal." J. Natl. Cancer
Inst. 71, 489-499 (1983).
Later, I used their data to check my theoretical approach
and thereby confirmed the result of their analysis:
F.A. Seiler, "Analysis of Health or Systemic Effects
Caused by Two Toxicants," Environment International, 13,
459-467, 1987.
I don't remember off the top of my head which models
Whittemore and McMillan used but I know that I tried all
kinds of synergistic, independent, and antagonistic models,
52 in all, and out on top came Whittemore's solution.
So I have already criticized the recent work of Jerry
Puskin for not considering that the mechanism of interaction
is known, so that the character of the 'confounder' is well
specified and should not be ignored.
HAVE A NICE WEEKEND ALL!
Fritz
*****************************************************
Fritz A. Seiler, Ph.D.
Sigma Five Consulting: Private:
P.O. Box 1709 P.O. Box 437
Los Lunas, NM 87031 Tome', NM 87060
Tel.: 505-866-5193 Tel. 505-866-6976
Fax: 505-866-5197
*****************************************************
-----Original Message-----
From: owner-radsafe@list.vanderbilt.edu
[mailto:owner-radsafe@list.vanderbilt.edu]On Behalf Of M Nivas
Sent: Friday, June 20, 2003 9:33 AM
To: radsafe@list.vanderbilt.edu
Subject: Synergistic
B. Cohen wrote:
No consideration is given to synergisms
between
these various pollutants, although such synergisms are
quite likely to
be
important.
No consideration was given to antaganism ether.
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