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RE: Laymans questions on hormesis and LNT
In general, any relatively healthy organism benefits from a moderate level of stress. To make a quantitative analysis of this would require MASSIVE data points and a ridiculous number of control subjects. I think this one is relegated to the realm of personal ideology. I chose to believe in hormesis.
Floyd W. Flanigan B.S.Nuc.H.P.
-----Original Message-----
From: John Jacobus [mailto:crispy_bird@YAHOO.COM]
Sent: Thursday, August 28, 2003 11:17 AM
To: BERNARD L COHEN; Dimiter Popoff
Cc: radsafe@list.vanderbilt.edu
Subject: Re: Laymans questions on hormesis and LNT
Dr. Cohen
I agree. That was what I was referring to by choosing
the appropriate end-point or result. Sometime you do
get what you are looking for.
--- BERNARD L COHEN <blc+@PITT.EDU> wrote:
>
> On Thu, 28 Aug 2003, Dimiter Popoff wrote:
>
> > Since I have been on this list I have read words
> like 'hormesis' and LNT
> > innumerable times and eventually - although I have
> no medical knowledge - I
> > have some questions.
>
> --I see no conflict between hormesis and LNT. LNT
> applies to
> cancer initiating DNA damage, and seems logical from
> that standpoint.
> However it must be recognized that this is added to
> a very large
> background of such DNA damage events occurring
> naturally, trillions of
> times per day in each person. If this were the only
> important thing, we
> would all die of cancer at a very young age.
> Hormesis arises from stimulation of repair enzyme
> production, stimulation
> of immune response, stimultion of apoptosis,
> modification of cell cycle
> timing, etc. There is no reason to believe that
> these vary linearly with
> dose, and there is direct evidence to the contrary,
> indicating that
> hormesis apples most to low level radiation.
> The only question is what happens when you add the
> two effects.
> There is strong evidence indicating that hormesis
> predominates for low
> level radiation. Where is the contrary evidence?
>
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=====
-- John
John Jacobus, MS
Certified Health Physicist
e-mail: crispy_bird@yahoo.com
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